White Blood Cells Flashcards
Which white blood cells are produced from the common myeloid progenitor?
Granulocytes - neutrophils, basophils and eosinophils
What is the difference between monocytes and macrophages?
Monocytes are in the blood whilst macrophages are in tissue
What are the main functions of neutrophil granulocytes?
Chemotaxis, phagocytosis and killing of phagocytosed bacteria
What are the main functions of basophils granulocytes?
Chemotaxis, phagocytosis, killing of phagocytosed bacteria, medication of immediate type hypersensitivity, modulates inflammation responses by releasing heparin
What is the main functions of eosinophils
Chemotaxis, phagocytosis, killing of phagocytosed bacteria, defense against parasitic infection
What is left shift?
When there is a presence of earlier forms of neutrophils eg band forms
How many lobes is normal for a neutrophil?
3-5
What is it called when there are more than 5 lobes in a neutrophil
Hyper segmented neutrophil
What are the steps of chemotaxis?
MARDi MP
Migration Adhesion Rolling Diapediesis Migration Phagocytosis
What is diapedesis?
When white blood cells migrate across the blood vessel wall
How many lobes do eosinophils contains?
2
What is contained within the granules of basophils?
Heparin, histamine and proteolytic enzymes
How do you identify basophils?
They have many granules in their cytoplasm
What do monocytes do?
Present antigens to lymphoid cells
How are macrophages related to iron?
They store and release iron
What white blood cells derive from the common lymphoid progenitor?
T cell, B cells and NK cells
What do B lymphocytes produce?
Antibodies
What do NK Cells do?
Part of innate immunity - kill tumour and virus infected cells
What is leucocytosis?
To many white blood cells of any type
What is meant by neutrophilia , basophilia and eosinophillia?
Too many of each type of white blood cell
What is leucopenia?
Too little of any type of white blood cell
What is the most abundant type of white blood cell?
Neutrophils