White blood cell

Question 1

In this disease, there will be markedly high IL-6

Answer 1

Multiple Myeloma

Question 2

What disease is associated with the Philadelphia chromosome> (9;22)

Answer 2

CML

Question 3

The following disease does NOT express CD21 or CD3

NK cell markers (CD16 and CD56) are positive

Answer 3

Extranodal NK cell lymphoma

Question 4

Pathogenesis: 12;21 RUNX1, ETV6

Answer 4

B-ALL

Question 5

What are the markers of hairy cell leukemia

Answer 5

CD19 
CD20 
CD11c 
CD25 
CD103 
Annexin A1

Question 6

Pathogenesis: NOTCH1

Answer 6

T-ALL

Question 7

When I say “starry sky cytoplasm”, you say…

Answer 7

Burkitt

Question 8

Pathogenesis: Deletions of 13q14.3, 11q, and 17p, or trisomy 12q

Answer 8

CLL/SLL

Question 9

What are the translocations that can be seen in Burkitt lymphoma?

What is NOT expressed in Burkitt lymphoma>

Answer 9

t(8;14)
t(2;8)
t(8;22)

BCL2 is not expressed

Question 10

What is Adult T cell Leukemia/lymphoma associated with? (another disease)

Answer 10

HTLV-1

Question 11

This disease is also known as Macrophage Activation Syndrome and a cytokine storm is characteristic in the disease course

Answer 11

Hemophagocytic Lymphohistiocytosis

Question 12

What mutation is seen in CML?

Answer 12

BCR-ABL mutation

Question 13

What is characterized by a t(15;17)

Answer 13

Acute promyeloid leukemia

Question 14

What is the translocation that is seen in Mantle Cell Lymphoma?

Answer 14

(11;14) on the IgH locus

Question 15

This disease has a rearrangement in the ALK gene. Who is she and what are her markers?

Answer 15

Anaplastic large cell lymphoma

CD30+

Question 16

This disease has a JAK2 mutation with an elevated hematocrit and increased RBC

Answer 16

polycythemia vera

Question 17

What is the translocation for follicular lymphoma? And what does she have the potential to turn into?

Answer 17

t(14;18)

Can turn into large B cell lymphoma

Question 18

The markers for this disease is CD3- and CD56+

Answer 18

Large Granular Lymphocytic Leukemia

Question 19

Markers: 
Tdt+ 
CD19 
CD20 
PAX5

Answer 19

B-ALL

Question 20

This disease is characterized by t(8;21): RUNX1 and Inv(16): CBFB

Answer 20

AML

Question 21

What are the markers for CLL/SLL

Answer 21

CD19
CD20
CD23
CD5

Question 22

The Tax protein is present in….

Answer 22

Adult T cell Leukemia/Lymphoma

Question 23

What are the markers for Multiple Myeloma?

Answer 23

CD138 +
Syndecan-1 positive
CD56

Question 24

What are the markers that are seen in Mantle cell lymphoma?

Answer 24

High cyclin D1 
CD19 and CD20 
High IgM and IgD 
CD5+ 
CD23-

Question 25

When I say CCR6 positive, you say

Answer 25

Langerhans cell histiocytosis

Question 26

This disease is characterized by a point mutation in BRAF

Answer 26

Hairy cell Leukemia

Question 27

The following markers describe which disease?

CD2
CD3
CD5

Answer 27

Peripheral T cell lymphoma

Question 28

Markers: 
Tdt+ 
CD1 
CD2 
CD5 
CD7  (T cell markers CD3, CD4, CD8, are negative)

Answer 28

T-ALL

Question 29

Which disease is associated with the following:
t(11;18)
t(14;18)
t(1;14)

Answer 29

Marginal Zone Lymphoma

Question 30

This disease has rearrangements present on IgH and a TP53 deletion on the 17th chromosome

Answer 30

Multiple Myeloma

Question 31

What is over expressed in Mantle cell lymphoma?

Answer 31

Cyclin D1

Question 32

What is the disease that is associated with a dysregulation of BCL6? What are her markers?

Answer 32

Diffuse Large B cell Lymphoma

B cell markers: CD19 and CD20

Question 33

In which disease is the Waldeyer ring found?

Answer 33

Diffuse Large B cell Lymphoma