Singh stuff

Question 1

aPTT measures the efficiency of which pathway?

Answer 1

Intrinsic pathway

Question 2

If aPTT is prolonged what should you be thinking?

Answer 2

VWF disease

Hemophilia

Question 3

Most vWF disease are autosomal _____

Answer 3

dominant; 50% chance of getting it from parents; so one of your parents has to have it

Question 4

Which test will be abnormal with hemophilia B?

Answer 4

There will be decreased activity of factors VIII and IX

Question 5

If a patient presents with a prolonged PTT that does not improve with mixing (mining in normal PTT), what can you conclude?

Answer 5

There is not a factor deficiency; this means that there is likely an inhibitor present; or an AUTOANTIBODY

Question 6

Describe acquired hemophilia

A, who gets it, what is it associated with?

Answer 6

older adults
Postpartum
Autoimmune diseases
sometimes malignancy

Question 7

D dimer can indicate what?

Answer 7

A thrombolytic event; The dDimer is secondary from fibrin break-ing up, which means that if there is a high D dimer, you know that there is a thromboembolism

Question 8

In the case of humoral hypercalcemia of malignancy, what is commonly seen in the labs?

Answer 8

Elevated calcium with a low phosphorus and a low PTH

PTHrP will be increased because of the cancer

Question 9

In the case of SIADH, what will be seen in the lab work?

Answer 9

Decreased sodium
Decreased serum osmolarity
increased urine osmolarity

Patient is keeping water but is getting rid of ions in the urine, and retaining free water because the tumor is releasing an ADH factor

Question 10

What is pembertons sign (redness in the face when the arms are raised over the head) commonly seen with?

Answer 10

Superior vena cava syndrome

Question 11

If the PT and PTT are elevated what can you infer?

Answer 11

That there is a defect in the classical pathway or you might have a DIC issue

Question 12

Auer rods are commonly seen in….

Answer 12

Acute promyelocytic leukemia

Question 13

What are the immediate treatments when someone is diagnosed with Acute promylocytic leukemia and is in DIC?

Answer 13

ATRA (arsenic trioxide) and ATO (all trans retinoid acid)

Question 14

As the white blood count gets closer to 100, what should you think?

Answer 14

LEUKEMIA

Question 15

What does a positive lap score tell you?

Answer 15

Non-neoplastic reaction; the lymphocytes take up the stain; if she is negative, think neoplasm

Question 16

Which disease has a correlation with the MYC gene translocation?

Answer 16

Burkitt lymphoma

Question 17

You have a patient that you are monitoring and you notice that their urine output decreases but there is an increase in sodium, potassium, serum creatinine, and BUN, what are you thinking?

Answer 17

Tumor lysis syndrome

Question 18

The Richter transformation is commonly seen in what disease?

Answer 18

CLL to a high grade lymphoma

Question 19

______ is any active or passive process that causes splenic enlargement

Answer 19

Splenomegaly

Question 20

_______ will manifest splenomegaly as a result of its contribution to the disease process

Answer 20

Hypersplenism

Question 21

Which vaccinations should you be SURE to give your splenectomized patients?

Answer 21

Streptococcus pneumonia’s
Neisseria meningitis
H flu