Werner's syndrome Flashcards
1
Q
Werner Syndrome
A
Think about “Adult progeria”, these patients are a “reck” (RECQL2/WRN gene)
- same as Progeria: bird like facies, sclerodermatous skin lesions, cerebrovascular/cardiovascular events
Plus:
- accelerated aging
- Malignancies (fibrosarcoma, osteogenic sarcoma)
- Cataracts
