Erythrokeratoderma Variabilis (Mendes da Costa syndrome)

Question 1

Erythrokeratoderma Variabilis (Mendes da Costa syndrome) sketch

Answer 1

• Picture the “Global Juggernaut Bro numero tres (GJB3)” - Mendes Da costa.
• He is A Dominant force in global exlopration (Autosomal dominant)

- picture him looking at a map “Connexing, the dots” (Connexin 31 and 30.3 defect)

• The magical moving map reminds you of the Geographic patches of erythema that changes shapes, along with the fixed hyperkeratotic lesions
• Picture him freaking out (emotion) when learning that wind and cold are in the forecast–> to remind you that these three things can exacerbate the rash
• He is shaving with the Retinoid razor- best treated with oral retinoids which will clear hyperkeratosis and improves Geographic erythema in many cases.