Wenger's granulomatosis

Question 1

What is the definition of ‘Wenger’s granulomatosis’

Answer 1

1. Autoimmune condition
2. Small vessel vasculitiis
3. Granulomas ( accumulation of immune cells )

Question 2

Name two ANCA associated vasculitis

Answer 2

1. Granulomatosis with polyangitis ( Wegener’s syndrome )

2. Microscopic polyangitis

Question 3

What is ‘Wegener’s triad’

Answer 3

1. Upper respiratory tract symptoms
2. Lower respiratory tract symptoms
3. Renal tract involvement

Question 4

Name 2 upper respiratory tract symptoms

Answer 4

1. Sinusitis
2. Epitaxis
3. ‘Saddle shaped nose deformity’

Question 5

Name 2 lower respiratory tract symptoms

Answer 5

1. Haemoptysis

2. Pulmonary infiltrates and nodules

Question 6

Name 2 renal tract symptoms

Answer 6

1. Haematuria

2. Rapidly progressing glomerularnephritis

Question 7

Name 3 investigations and results for Wegener’s granulomatosis

Answer 7

1. FBC
2. Chest Xray
3. Renal biopsy and urinalysis

Question 8

What are the result of blood tests?

Answer 8

1. cANCA positive

Question 9

What are the result of chest x - ray?

Answer 9

1. Caviating lesions

Question 10

What does a renal biopsy show?

Answer 10

Epithelial crescents in Bowman’s capsule

Question 11

How is a diagnosis of Wegener’s granulomatosis made?

Answer 11

Skin biopsy shows accumulation of neutrophils in the vessels

Question 12

How is Wegener’s granulomatosis managed?

Answer 12

1. Steroids

2. Long term immunosupression - Cyclophosphomide