Churg Strauss syndrome

Question 1

What is the definition of Churg-Strauss syndrome?

Answer 1

1. ANCA associated small-medium vessel vasculitis

2. Atopy associated condition

Question 2

3 stages of development of Churg Strauss syndrome?

Answer 2

1. Asthma / allergic rhinitis
2. Hyper eosinophilia - can cause tissue damage to lungs/GI
3. Vasculitis - leads to cell death and can be life threatening

Question 3

Name 4 symptoms of Churg Strauss syndrome?

Answer 3

1. Asthma / dyspnea
2. nasal polyps
3. haemoptysis
4. mononeuritis multiplex

Question 4

How do patients with Churg Strauss present?

Answer 4

adult onset asthma coupled with rhinitis, sinusitis and nasal polyps

Question 5

Name 3 investigations that should be carried out?

Answer 5

1. Blood tests for antibodies
2. Chest X ray
3. Biopsy

Question 6

What are the results of blood tests in Churg strauss?

Answer 6

1. High igE

2. pANCA positive

Question 7

What does a biopsy show?

Answer 7

small necrotising vasculitis

Question 8

Name two drugs can can cause Churg Strauss?

Answer 8

1. Leukotriene receptor antagonist

2. mesalazine (tx for crohns)