welz Flashcards
a German surgeon and pathologist who first described welz tumor
Dr. Max Wilms
Wilms tumor, also known as
nephroblastoma
ETIOLOGICAL CAUSES AND FACTORS
Genetic alterations development of
the genitourinary tract.
family history of Wilms tumor
Having persistent metanephric tissue or
nephrogenic rests
Have a urological disorder
two embryological
structures that give rise to the kidney
metanephric
blastema
metanephric blastema that grow after 36 weeks of gestational age are called
nephrogenic rests.
nephrogenic rests are associated with
nephroblastomatosis
a precursor
lesion to Wilms tumors.
nephroblastomatosis
Wilms tumor can occur as part of rare
syndromes.
WAGR syndrome
Denys-Drash syndrome
Beckwith-Wiedemann syndrome
disorder
that affects many body systems and
is named for its main features
WAGR syndrome
WAGR syndrome stands for
Wilms tumor, Aniridia, Genitourinary anomalies, and a Range of developmental delays
characterized by kidney disease that
begins within the first few months of
life
Denys-Drash syndrome
classified as an
overgrowth syndrome, which means that affected infants are larger than
normal
Beckwith-Wiedemann syndrome
PHYSICAL EXAMINATION d is usually identified when a
caregiver notices a
abdominal swelling
color of patient
pallor
The mass is typically confined to what area
flank area
is common due to
increased renin secretion from the
tumor.
Hypertension
e present in 20% of cases.
hematuria
metastatic signs such as
respiratory distress (lung metastasis) or
hepatomegaly
Create image of the kidneys help find whether a child has a kidney tumor
Imaging test
test to determine if the
cancer has spread (metastasized):
Abdominal ultrasound
Bone scan
CT scan
Chest X-ray
MRI
tissue is removed and
examined under a microscope
Biopsy
Uses by healthcare provider
throughout europe
● Uses surgery after chemotherapy to
do the staging
International Society of Paediatric
Oncology (SIOP)
● Uses surgery to stage the tumor
before chemotherapy
Children’s Oncology Group (COG)
s the name for the way that healthcare
providers determine if and how far the cancer has
spread beyond its original location
Staging
Found only in your child’s kidney
● Removed completely after surgery
What stage:
Stage I
What stage: Tumor has grown past your child’s
kidney
● Also remove completely
Stage II
What stage: ● Tumor is not able to be remove
completely
● Some tissue remains in your child’s
abdominal area
Stage III
What stage: Tumor has grown beyond your
child’s abdomen and pelvis to
places like their lungs, liver, bone, or
brain
Stage IV
What stage: V
● Tumor is bilateral, or present in both
kidneys
● Provider will do staging on each
kidney separately
Stage V
chemo drugs
used most often are:
Actinomycin D (dactinomycin)
● Vincristine
Short-term side effects can include:
● Hair loss
● Mouth sores
● Loss of appetite
● Nausea and vomiting
Drug-specific side effects
Vincristine can damage nerves.
Doxorubicin can damage the heart
tingling, numbness,
weakness, or pain, particularly in the
hands and feet
peripheral neuropathy
