Weight Loss Drugs

Question 1

How does Orlistat work?

Answer 1

binds to and inhibits gastric and pancreatic lipase, so prevents absorption of 30% of dietary fat

Take AFTER meal

Question 2

Side effects of Orlistat?

Answer 2

GI distress- flatulence, diarrhea, fecal urgency, oily stools

Question 3

Supplement what with Orlistat?

Answer 3

ADEK (fat soluble) vitamins, co prescribe MVI 1 PO QD

Question 4

How do you know if you have enough Vit C?

Answer 4

Pee is yellow

Question 5

What is Phentermine?

Answer 5

1960s drug that increase metabolic rate, sympathomimetic activator of CNS.

Short term TX 12 weeks given QOM (every other month)

Question 6

How does Lorcaserin work? Who gets it? How long do they get it?

Answer 6

Serotonin-2 receptor agonist, tricks brain into thinking you are full.
Pt with BMI > 30 with 1 risk factor
BID x 12 weeks, lose 5% of body weight within 12 weeks or discontinue because it won’t work

NOT WITH PREGNANT PATIENTS

Question 7

What is Topiramite?

Answer 7

anti-epilectic, indirect acting on the CNS

Question 8

Name 4 other weight loss drugs

Answer 8

Topiramate
Bupropion
Zonisamide
Ribonabant (cannabinoid blocker)