Alpha Blockers

Question 1

postsynaptic alpha 1 receptors mediate what?

Answer 1

Vasoconstriction

Question 2

presynaptic alpha 2 receptors mediate what?

Answer 2

inhibition of neurotransmitter release

Question 3

If presynaptic alpha 2 senses epi/NE it tells presynaptic neuron to ____ ne/epi output

Answer 3

decrease

Question 4

what is MOA of alpha 2 blocker drug be?

Answer 4

presynaptic alpha 2 receptor agonist, binds and stimulates receptors

says do not put out epi/NE

Question 5

Alpha 1 blockers end in what?

Answer 5

“-azosin”

Question 6

Alpha 1 blockers used in what?

Answer 6

decrease BP

Question 7

Alpha 1 receptors are also where? what happens with stimulation? Who give a blocker?

Answer 7

Bladder, when stimulated causes urinary retention

when blocked increase urinary flow (give to grandpa with BPH)

Question 8

What is the opposite of a Alpha 1 blocker?

Answer 8

alpha 1 agonist–

pseudophed (vasoconstriction)

so caution in patients with HTN so use spray so no systemic effects

Question 9

Clonidine is what? comes how? is it good or bad?

Answer 9

alpha 2 agonist for HTN

comes orally and patch

sucky anti-hypertensive, used for unstable HTN or can’t tolerate other BP medications

Question 10

Dexmedetomidine is what (3 things)

Answer 10

Centrally acting (CNS)
Lipophilic
IV

Alpha 2 agonist

Question 11

Dexmedetomidine used for what? Be careful and monitor what?

Answer 11

Sedation with very little respiratory depression

monitory BP (hypotension)