Wegner's

Question 1

What is wegner’s?

Answer 1

granulomatous with polyangiitis is a systemic autoimmune small vessel vasculitis

Question 2

What does Wegner’s usually affect?

Answer 2

upper and lower respiratory tract along with pauci-immune glomerulonephritis

Question 3

What is the upper airway presentation of Wegner’s?

Answer 3

1. nasal obstruction
2. ulcers
3. epistaxis
4. saddle shaped deformity of nose

Question 4

What is the lower airway presentation of Wegner’s?

Answer 4

cough and haemoptysis

Question 5

What is the renal presentation of Wegner’s?

Answer 5

rapidly progressive glomerulonephritis causing haematuria and red cell casts

Question 6

What can other presentations of wegner’s be?

Answer 6

1. purpura
2. nodules
3. peripheral neuropathy
4. arthritis/athralgia

Question 7

What bloods and results would be shown on wegners?

Answer 7

1. ESR/CRP- elevated

2. c-ANCA- positive- highly specific

Question 8

What other investigations are done?

Answer 8

1. urinalysis and microscopy

2. CT chest

Question 9

What would urinalysis and micrscopy show?

Answer 9

• haematuria

- RBC casts

Question 10

What would CT chest show?

Answer 10

lung nodules and infiltrates

Question 11

What is the medical management for Wegner’s?

Answer 11

Corticosteroids (prednisolone)

Question 12

What are possible complications for wegners?

Answer 12

Corticosteroids side effects

Question 13

What antibody is wegners?

Answer 13

c-Anca