Behcet's Disease Flashcards
1
Q
What is Behcet’s disease?
A
Systemic inflammatory vasculitis which is associated with HLA-B51
2
Q
Where is Behcet’s common?
A
along the old silk road from the Mediterranean to China
3
Q
What is the cause of behcet’s?
A
Possibly neutrophil hyper-reactivity but not well understood
4
Q
What gene is associated with Behcet’s?
A
HLA-B51
5
Q
What is the presentation of Behcet’s?
A
- Recurrent aphthous ulcers
- Genital ulcerations
- Erythema nodosum
- Thrombophlebitis
6
Q
What investigations are done for Behcet’s?
A
- Usually clinical diagnosis:
2. Can perform pathergy testing (stick a needle in forearm and papule forms in 48 hours)
7
Q
What is the management of the orogenital ulceration?
A
topical steroids are sufficient
8
Q
What is the management of organ involvement in Behcet’s?
A
prednisolone plus immunosuppressant (usually azathioprine)
9
Q
What are DDx for Behcet’s?
A
- Crohn’s
2. UC
