Week 9 - tues Flashcards
Wha are iPSCs and what are they used for?
Induced pluripotent stem cells
-make de-differentiated versions of our own cells (stem cells)
True or false: Stem cells are found in the body
False
-Adults do not have stem cells
Where are stem cells found?
-Bone marrow
-Umbilical cord/placental blood
How are multipotent cells limited?
They cannot fix your own disease if it is genetic
True or false: your own stem cells can be used for genetic disease
False
True or false: a donor (family member) stem cells can be used for genetic disease
True
Allogenic stem cells
Multipotent cells from a relative
Autologous stem cells
Your own multipotent stem cells
What are the 2 failure types researchers want to ensure epigenome is normal
- Retained memory of differentiated (was not reprogrammed)
- Induction specific abbreviations –> something went wrong
Proteome
Collection of protein molecules present in the cell
What controls translation efficiency in prokaryotic mRNA
-Different ribosome binding sites have different rates of translation initiation
-Shine Dalgarno sequence
What controls translation efficiency in Eukaryotic mRNA
Secondary structures slow rate of translation
More secondary structures = less fast translation since ribosomes have to push through
Which is more prone to misfolding: Optimal or rare codons?
Optimal
What controls degradation rate
Proteasome
True or false: We can sequence proteins through Illumina seq
False
-there is no version of illumina seq
