Week 8-Evolution Flashcards

1
Q

How are evolution and natural selection linked? Give an example

A

-These ideas date back to Darwin and the work he did observing different species of different members of the same species and the variation between them and why that might be.

-The environment cannot support unlimited growth – there’s a finite amount of space, air and food that organisms have to be in competition for and that the ones who are best adapted to the environment will win. So organisms vary in traits that have been selected in or out.

Example:
-Green beetles are more easily seen by birds that brown beetles, who can blend in to the soil, so green beetles are more likely to be eaten. Brown beetles survive and reproduce passing this trait onto their offspring=more brown beetles than green beetles in the population.
-We can say that the advantageous trait of having brown colouring has been selected in by a selection pressure, the predation by birds, and the beetles have been bred to have this colouring.

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2
Q

What are the 4 big principles of Evolution and natural selection?

A
  1. Principle of natural design for gene replication
  2. Superabundance
  3. Natural variation
  4. Selection pressures
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3
Q

Define the Principle of natural design for gene replication

A

We are a unique constellation of genes that drive physiological processes and behaviours. Evolution does not operate in individuals, rather evolution operates in genes. Genes giving us a genetic advantage need to make it to the next generation

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4
Q

Define Superabundance

A

Animals and plants produce more offspring than necessary. This is because at least one or more will be well adapted to the environment, survive, and pass on those genes.

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5
Q

Define Natural Variation

A

Each offspring is somehow different (unique gene combination produces different offspring variation=different likelihoods of surviving an environment.)

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6
Q

Define Selection Pressures

A

a) Natural selection pressures: Organisms must ensure that the genes survive so they can make it to the next generation

-Natural pressures=predation of beetles by birds
-Imposed pressures=selective breeding in dogs

Selection pressure: predation, susceptibility to disease and toxins, dangerous environment

-Organisms respond to these pressures through ADAPTATIONS

-BUT adaptations tend to have a trade off price to pay as the smaller the trade off the better the adaptatio

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7
Q

Define the Environment of evolutionary adaptiveness (EEA)

A

How the environment was when we evolved

-We can estimate and look at what the environment and selection pressures were like back then by looking at traits that occur universally, like the brown on the beetles, by looking at things that happen with everyone and was evolved and an advantage.

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8
Q

What behaviours or traits occurring universally in all cultures, are good candidates for evolutionary adaptations?

A

-The ability to infer others’ emotions (to determine if they’re a threat)

-To discern kin from non-kin (important for mating as mating within family is bad in terms of genetics)

-To identify and prefer healthier mates (to pass genes on)

-To cooperate with others (important for working in groups and group benefits)

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9
Q

Why can humans compete with other species?

A

-Agile hands: Can use tools

-Colour vision: Can detect opportunities and dangers

-Mastery of fire

-Bipedalism(walk on 2 feet): Walk long distances, carry tools, food and infants

-Linguistic abilities: Pass information, make plans, form complex civilisations

-Large complex brain has the power to do all of the above

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10
Q

What 2 facts were not understood at the time when Darwin (1809-1882) created the theory of evolution?

A
  1. Why members of the same species differ from one another, we are actually all different
  2. How anatomical, physiological and behavioural traits are passed from parents to offspring

-An unread manuscript in his files contained the answers , it had been sent to him by an Augustinian monk called Gregor Mendel, unfortunately for both the significance of mendel’s research was not recognised until the early part of 20th century

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11
Q

How did Mendel begin his studies on heredity?

A

-Mendel began his studies on heredity using mice. He was at St. Thomas’s Abbey but his bishop did not like one of his friars studying animal sex (mice), so Mendel switched to plants.

-Mendel also experimented with hawkweed (Hieracium)[32] and honeybees. He published a report on his work with hawkweed,[33] a group of plants of great interest to scientists at the time because of their diversity. However, the results of Mendel’s inheritance study in hawkweeds was unlike his results for peas; the first generation was very variable and many of their offspring were identical to the maternal parent.

-In his correspondence with Carl Nägeli he discussed his results but was unable to explain them.[32] It was not appreciated until the end of the nineteen century that many hawkweed species were apomictic, producing most of their seeds through an asexual process.

-None of his results on bees survived, except for a passing mention in the reports of Moravian Apiculture Society.[34] All that is known definitely is that he used Cyprian and Carniolan bees,[35] which were particularly aggressive to the annoyance of other monks and visitors of the monastery such that he was asked to get rid of them.[36] Mendel, on the other hand, was fond of his bees, and referred to them as “my dearest little animals”.[37]

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12
Q

What are Dichotomous traits and how did Mendel study this?

A

-Mendel (1822-1884) studied inheritance in pea plants

-He studied dichotomous traits, and he began his experiments by crossing the offspring of true breeding lines.

-DT: These are traits that occur in one form or the other, never in combination: eye colour in humans or pea colour in peas

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13
Q

What are True Breeding Lines?

A

-They are breeding lines in which interbred members always produce offspring with the same trait, generation after generation. In the pea case it would be green seed or yellow seed.

-Mendel crossed 2 different true breeding lines and then their offspring. One trait, dominant traits, appeared in all of the first generation offspring. The other trait which he called the recessive trait, appeared in about one quarter of the second generation offspring.

-Pure-bred dogs have identical offspring

-dominant=yellow recessive=green

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14
Q

Define Genotype and Phenotype

A

G: It’s the combination of alleles on organism inherited from its parents (genes)

P: It’s the organisms appearance (physical) (i.e., an organism’s observable trait)

-2 people with straight hairlines cannot pass widows peak on to offspring (2x ww)

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15
Q

What was Mendel’s first idea to explain his results?

A

There are two kinds of inherited factors for each dichotomous trait - today the inherited factor is called gene.

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16
Q

What was Mendel’s second idea to explain his results?

A

Each organism possesses 2 genes for each of its dichotomous traits. In the case of widow’s peak the genes would be W and w

-2 genes that control the same trait are called alleles (in case of pea colour would be Yellow and Green, in case of widow’s peak would be W and w).

-Organisms that possess 2 identical genes for a trait that are said to be homozygous and those possess 2 different genes for a trait are said to be heterozygous for that trait.

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17
Q

What was Mendel’s third idea to explain his results?

A

One of the two genes for each dichotomous trait dominates the other in heterozygous organisms

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18
Q

What was Mendel’s fourth idea to explain his results?

A

Dichotomous trait, each organism randomly inherits one of its father’s two factors and one of its mother’s two factor (we know this happens randomly as otherwise everyone in a family would look the same)

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19
Q

What are chromosomes?

A

-Not until the early 20th century, genes were found to be located on chromosomes

-Chromosomes occur in matched pairs (with ONE exception aka pair 23), and each species has a characteristic number of pairs in each of its body cells

-Humans have 23 pairs

-The two genes that control each trait are situated at the same location (loci), one on each chromosome of a particular pair

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20
Q

What are Sex chromosomes and sex-linked traits?

A

-There is only one exception to the rule that chromosomes always come in matched pairs

-Traits that are influenced by genes on these chromosomes are referred to as sex linked

-Traits that are controlled by genes on the sex chromosomes occur more frequently in one sex than the other

-If the trait is dominant it will occur in females because females have twice the chance of receiving the X chromosome

-Recessive sex linked diseases occur more frequently in males (Haemophilia, colour blindness)

-Gene for blood clotting is on X chromosome so more likely in males if one damaged X chromosome

-Turners syndrome (just one X chromosome in females)

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21
Q

What is meiosis?

A

-The process of cell division that produces gametes (egg or sperm cell) is called meiosis

-Chromosomes divide, and one chromosome of each pair goes to each of the two gametes that result from the cell division

-Information is shared and crossed over

-Sperm + egg = zygote

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22
Q

What is the crossing over of chromosomes?

A

-As a result genetic recombination, each of the gametes that formed the zygote that developed into you contained chromosomes that were unique

-In contrast to the meiotic creation of the gametes, all the cell division in the body occurs by mitosis

-Important for evolution and natural selection as produces variation

23
Q

What is the structure of a chromosome/DNA?

A

-Each chromosome is a double stranded molecule of deoxyrybonucleic acid (DNA)

-Each strand is a sequence of nucleotide bases attached to a chain of phosphate and deoxyribose

-There are 4 bases

-The 2 strands that compose each chromosome are coiled around each other and bonded together by the attraction of adenine for thymine and guanine for cytosine

-Chain of amino acids forms protein

-2 strands as one is used as a template when cells divide

24
Q

Why is chromosome replication essential to go right?

A

-Replication is a critical process of the DNA molecule. Without it, mitotic cell division would not be possible

-The process needs to be accurate. Sometimes mistakes happen aka mutations

-In most cases, mutations disappear from the gene pool within a few generations because the organisms that inherit them are less fit

-In rare instances, mutations increase fitness and in so doing, contributes to rapid evolution.

25
Q

What are some beneficial mutations produced we have?

A

-Do not get high cholesterol

-Are resistant to HIV

-Are resistant to malaria

-Tolerate cold temperatures better

-Tolerate high altitude

-Have crystal-clear underwater vision

-Have super-dense bones

-Need less sleep

26
Q

How can mutations occur via an external agent?

A

-Mutations can occur via an external agent such as UV radiation in skin cancer

-Cell division doesn’t stop=tumour

-These tiny changes can have big consequences e.g., change in haemoglobin sequence can cause sickle cell disease

27
Q

Mutations can be divided into what 2 types?

A
  1. Chromosome mutations: Change in chromosome number or chromosome structure: Down’s syndrome
  2. Single-gene mutations: change in DNA structure within a particular gene: sickle cell disease

-Sometimes they don’t always have negative consequences e.g., joint toes formed in the womb

-We say radiation is bad as it can changes the structure of ovaries and testes which will be passed onto offspring

28
Q

What is the Mechanism of gene expression?

A
  1. Strand of DNA unravels
  2. Transcription: Messenger RNA (mRNA) synthesised from DNA
  3. mRNA leaves the nucleus and attaches to ribosome in the cell’s cytoplasm
  4. Translation: Ribosome synthesises protein according to 3-base sequences (codons)

-Codons are translated into amino acids forming a chain of protein

29
Q

What are Enhancers?

A

-Structural genes comprise only a SMALL portion of the chromosome

-Enhancers are stretches of DNA whose function is to determine whether particular structural genes initiate the synthesis of proteins and at what rate

-This determines how a cell will develop and how it will function once it reaches maturity

-Proteins that bind to DNA and influence the extent to which genes are expressed are called transcription factors

-Transcription factors control the enhancers. Transcription factors are influenced by signals received by the cell from its environment

30
Q

What makes an organism complex?

A

Its ability to synthesise proteins

31
Q

What is the Human Genome Project?

A

-One of the most ambitious scientific projects of all times, it began in 1990

-Its purpose was to compile a map of the sequence of all 3 billion bases in the human chromosomes

-It was assumed that once the human genome was described it would be relatively straightforward to link variations in the genome to particular diseases and then develop treatments

The 3 major contributions of the project were:
1. Development of new techniques to study DNA
2. The discovery that humans have a relatively small number of genes (20,000)
3.Only about 2% of chromosome segments contain protein-coding genes

-This discovery led to the rapid growth of a new field of research: epigenetics

-Wasn’t straightforward as we found most of our genomes are unstructural (i.e., cannot synthesise proteins)

32
Q

What is epigenetics and how has research in this grown?

A

-Epigenetic focuses on mechanisms that influence the expression of genes without changing the genes themselves

-It refers to modifications of DNA and DNA packaging that alter the accessibility of DNA and potentially regulate gene expression WITHOUT changing the sequence of DNA

-Assumed to be the means by which a small number of genes are able to orchestrate the development of humans in all their complexity

-It focuses on the role of experiences in genetic expression

-Many epigenetics mechanisms have been discovered, 2 of the most widely studied are DNA methylation and histone remodelling

33
Q

What is the difference between an epigenetics modification and a mutation?

A

The difference is a mutation is a change in the DNA sequence whereas epigenetic has DNA structure changing the same, with additional stuff added to it to synthesise proteins

34
Q

What are 2 of the most widely studied epigenetics mechanisms?

A
  1. DNA methylation
  2. Histone remodelling (Histone=protein with DNA wrapped around)
35
Q

What 2 major reasons is DNA methylation commonly studied in human populations?

A
  1. It is easily quantifiable and relatively stable
  2. Does not require complex processing of samples after collection
36
Q

What is one of the main roles of DNA methylation?

A

-One of the main roles of DNAm is in cellular differentiation. As stem cells divide and gradually differentiate into specific cell types. DNAm patterns become increasingly cell type specific

-This explains how cells with the same genetic sequence, such as neurons and white blood cells, have very different functions

-Thus in contrast to genetic information. DNAm is HIGHLY tissue specific

-The more specialised a cell is, the more methylation it has

37
Q

What does the DNA methylation mechanism allow?

A

-These mechanism allows for the cell-to-cell transmission of epigenetic patterns associated with the cell’s past exposures - they create a form of cellular memory that can be passed along to daughter cells

-When cells divide, tags get passed on aswell

-It is these patterns that can be detected in studies examining associations between current DNAm and exposures or events in the past

38
Q

Why is reprogramming important?

A

-We used to think that a new embryo’s epigenome was completely erased and rebuilt from scratch.

-Reprogramming is important because eggs and sperm develop from specialised cells with stable gene expression profiles

-In other words, their genetic information is marked with epigenetic tags. Before the new organism can grow into a healthy embryo, the epigenetic tags must be erased.

39
Q

What was the belief about how a new embryo’s epigenome is constructed?

A

-So basically the belief was that a new embryo’s epigenome had to be completely erased and rebuilt from scratch.

-This needs to be done in order for an embryo to make every type of cell in the body.

-However this is not entirely true. Some epigenetic tags remain in place as genetic information passes from generation to generation, a process called epigenetic inheritance.

-Epigenetic inheritance is an unconventional finding. It goes against the idea that inheritance happens only through the DNA code that passes from parent to offspring.

-It means that a parent’s experiences, in the form of epigenetic tags, can be passed down to future generations.

-In mammals, about 1% of genes escape epigenetic reprogramming through a process called imprinting

40
Q

What is meant by Transgenerational Epigenetics?

A

-These mechanisms can be induced by particular experiences such as neural activity, hormonal state, changes to the environment

-These changes can last a lifetime

-The interesting question is: Can those experience-induced changes be passed to your offspring?

-Yes, it was first observed in plants but now also evidenced in mammals: Mice trained to associate electric shock to odour. Then, bred for subsequent generations finding offspring also have this innate association.

41
Q

Why does making a case for Transgenerational epigenetic in humans challenging?

A

Making a case for epigenetic inheritance in humans remains especially challenging because:
-Humans have long life spans, making it time consuming to track multiple generations
-Humans have greater genetic diversity than laboratory strains of animals making it difficult to rule out genetic differences
-Ethical considerations limit the amount of experimental manipulation that can take place

-However…there are few hints that suggest it could be happening

42
Q

Transgenerational epigenetics: What was found when Geneticists analysed 200 years worth of harvest records from Overkalix, a small town in Sweden? (Kaati et al 2002; Bygren et al 2014)

A

-Analysed this because they tended to have good harvest records in that town

-They saw a connection between food availability (large or small harvests) in one generation and the incidence of diabetes and heart disease in later generations.

-The amount of food a grandfather had to eat between the ages of 9 and 12 was especially important. This is when boys go through the slow growth period (SGP), and form the cells that will give rise to sperm.

-Grandsons of Överkalix boys who had experienced a “feast” season when they were just pre-puberty died (often of diabetes) on average six years earlier than the grandsons of Överkalix boys who had been exposed to a famine season during the same pre-puberty window.

-When a statistical model controlled for socioeconomic factors, the difference in lifespan became 32 years, all dependent simply on whether a boy’s grandfather had experienced one single season of starvation or gluttony just before puberty.

43
Q

What could give a potential explanation for the Sweden Harvest study?

A

-As sperm cells form, the epigenome is copied along with the DNA

-Since the building blocks for the epigenome come from the food a boy eats, his diet could impact how faithfully the epigenome is copied

-The epigenome may represent a snapshot of the boy’s environment that can pass through the sperm to future generations

44
Q

What did Fraga et al. (2005) find doing a twin study of epigenetic effects?

A

They obtained tissue samples from 40 pairs of MZ twins, age range 3-74 years:
-Screened tissues for DNA methylation and histone modifications

-MZ twins were epigenetically indistinguishable in early life but differences accumulated as they aged

-The discovery of epigenetic differences in MZ twins raises the possibility that epigenetics differences might explain why one twin develops a disease and the other does not

-Basically the last conclusion means that if it was completely genetic MZ twins would be more concordant than DZ twins, as they are the same the changes must be environmental

45
Q

Interaction of genetic factors and experience: What is selective breeding of “maze bright” and “maze dull” rats?

A

-Early psychologists assumed that behaviour develops largely through learning.

-In 1934 Robert Tryon (Behavioural psychologist) trained a large heterogenous group of laboratory rats to run a complex maze. The rats received a food reward when they reached the goal box.

-Then mated the females and males that least frequently entered incorrect alleys during training : maze bright, and bred the females and males that most frequently entered incorrect alleys during training: maze dull (i.e., bred the best together and worst together)

-Then accessed the performance of offspring and kept mating brightest and dullest for 21 generations.

-By the eighth generation, there was almost no overlap in the maze learning performance of the 2 groups

46
Q

What was the results for the selective breeding of “maze bright” and “maze dull” rats?

A

-The maze bright rats were superior maze learners not because they were more intelligent but because they were less fearful - a trait that is not adaptive in many natural environments

-Selective breeding studies have proved that selective breeding based on one behavioural trait usually brings a host of other behavioural traits with it.

-Eight generation shows no overlap and show similar scores

47
Q

What is the difference between the development of individuals VS the differences among individuals?

A

In the development of individuals, the effects of genes and experience are inseparable WHEREAS in the development of differences among individuals they are separable

48
Q

What is the Adoption studies: the most extensive study is the Minnesota Study of Twins Reared Apart?

A
  • 59 pairs on monozygotic and 47 pairs of dizygotic twins who had been reared apart (not together) and as many pairs that had not.
  • Age range: 18-69 years.
  • Each twin was brought to University of Minnesota for approximately 50 hours of testing: intelligence and personality.

-Basically, due to all the interactions we explained before it is impossible to separate what is exclusively genetic and what exclusively environmental in the development of an individual.

-In contrast if you want to study how these factors affect the development of individuals they can be separated.

-If I look at you now I can’t say what is genetic and what is environmental , but if I look at all of you and try to look let’s say at the state of your arteries I could look at environmental effects that could have altered it

-Monozygotic=identical dizygotic=non-identical

49
Q

Would the adult monozygotic twins reared apart be similar or different?

A

-The study was remarkably consistent, both internally and externally.

-In general adult monozygotic twins were more similar to one another on ALL dimensions than dizygotic twins regardless how they were reared.

-This takes us to the contribution of genetic variation to this study.

-Heritability estimate: numerical estimate of the proportion of variability that occurred in a particular trait in a particular study as a result of genetic variation.

50
Q

What is Heritability estimation?

A

-Numerical estimate of the proportion of variability that occurred in a particular trait in a particular study as a result of genetic variation.

-Numerical estimate (between 0-1). Sometimes represented as percentages (100% would be 1).

-Basically you MUST have VARIATION in a trait to be able to get a value above 0

This means that:
A) It cannot be studied in one individual
B) The trait that you are exploring has to show variability in the population

-Bipedalism would be 0 because there is no variability in the trait. For instance “walking on two legs” is a human trait which does not vary much. When it does vary, this is usually due to environmental variations, such as accidents where people lose the function of one or both legs.

-As a consequence, “walking on two legs” has an h² close to 0. This does not mean that genes are not necessary for humans to walk on two legs. What it means is that variation in this trait is caused by primarily non-genetic factors.

51
Q

What does the numerical estimate depend on?

A

-The estimate depends upon which population you examine.

-Numerical estimate of the proportion of variability that occurred in a particular trait in a particular study as a result of genetic variation.

-For example the heritability of hair colour in a Chinese population would be quite low, and here quite high.

-This is because in China there is little “natural” variation in hair colour – variation that is genetically caused. As such, any large variations are usually due to environmental factors, such as artificial dyes.

-As heritability is a measure of the causes of variation in traits, things which we ordinarily think of as having a genetic basis can turn out to have low heritability.

-Another strange consequence of heritability is that the estimate depends upon which population you examine.

-For example the heritability of hair colour in a Chinese population would be quite low, yet in Australia would be quite high. This is because in China there is little “natural” variation in hair colour – variation that is genetically caused. As such, any large variations are usually due to environmental factors, such as artificial dyes.

-So while heritability does measure the causal impact of genes, it does so in a very specific and limited way.

52
Q

What does the magnitude of a study’s heritability estimate depend on?

A

-The magnitude of a study’s heritability estimate depends on the amount of genetic and environmental variation from which it was calculated and it CANNOT be applied to other situations.

-For instance, in the Minnesota study there was little environmental variation: all participants raised in industrialised countries by parents who met the standards for adoption.

-Therefore in this case variation in intelligence and personality would come from genetic variation.

-If the twins had been adopted by parents of completely different culture the heritability estimates for IQ and personality would have been lower .

-In representative Western samples all complex traits that have been studied have substantial heritability estimates: most between 40 and 80%.

-Genetic variation lower

53
Q

What did Turkheimer et al. (2003) find measuring the heritability of intelligence?

A

-Heritability of intelligence in upper-middle class 75%

-Heritability intelligence in 7y old twins: families from low SE status: 10% and high SE status 70%

-This effect was replicated and extended to other age groups

-Implications: intelligence develops from the interaction of genes and experience, one can inherit the potential to be of superior intelligence but this potential is rarely realised in a poverty stricken environment

-This has implications for the programs to help to develop individuals in low SE status.