Week 8 - Antifungals

Question 1

Common fungal infections of the Lower limb

Answer 1

Tinea pedis - interdigital, hyperkeratotic, inflammatory, ulcerative

Onymycosis (tinea ugium)

Question 2

Common drugs to perscribe fungal infections

Answer 2

azoles
allylamines

Question 3

Azoles MOA

Answer 3

interrupting the synthesis from lanosterol to ergosterol
fungistatic

Question 4

Allylamines

Answer 4

inhibits squalene epoxidase, fungicidal

Question 5

nystatins

Answer 5

binds to ergosterol in the fungal cell membrane

Question 6

Griseofulvin

Answer 6

disrupts spindle formation
no longer a popular treatment choice as it impacts male and female fertility
effective quicker treatment but longer treatment coarse

Question 7

Corticosteroids in the treatment of fungal infection

Answer 7

needs to be used in conjunction with antifungals. corticosteroids decreases the redness, as it allows fungal to grow

Question 8

when to use oral therapy instead of topical

Answer 8

• widespread tinea
• not responding to the topical treatment
• recurs soon after topical treatment
• is inflammatory or hyperkeratotic

Question 9

Lenght of treatment time for topical

Answer 9

terbinafine - 2 to 6 weeks for skin turnover time
azole - daily for 4 weeks, double the dose for 7 days

Question 10

lenght of treatment time for nail fungal infection

Answer 10

terbinafine - 12 weeks
azole - weekly for 26 to 52 weeks

Question 11

Terbinafine contraindication

Answer 11

• hepatic impairment
• psoriasis
• children

Question 12

Adverse effects of terbinafine

Answer 12

Oral = GI and taste disturbances -
Topical - generally well tolerated, may cause rare redness, itching, swelling

Question 13

amorolfine

Answer 13

penetrates nail and diffuses into nail bed