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Clinical therapeutics > week 3 - NSAIDs and Glucocorticosteroids > Flashcards

week 3 - NSAIDs and Glucocorticosteroids Flashcards

1
Q

NSAIDS and soft tissue

A
  1. Inflammatory mediators repair
  2. local tissue damage - platelet derived growth factor
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1
Q

NSAIDS indications

A

Gout
RA
inflammatory arthropathies
OA
headache
mild/moderate acute tissue damage
etc

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2
Q

NSAID issues

A

heart problems
hypertension
GI issues
renal impairment

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3
Q

NSAID drug interactions

A

ACE inhibitor
diuretics
warfrin
methotrexate
other NSAIDS

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4
Q

Minimising toxicity

A

change dose
topical
renal impairment

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5
Q

How do glucocorticoid works

A

immunosuppressive by reducing amount of immunocompetent cells out of circulation

inhibit phosphilpase A2 = leukotrienes are inhibited

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6
Q

Dangerous impacts of glucocorticoids

A

skin ulceration
immunocompressed patients
diabetic patients

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7
Q

Adverse effects of topical corticosteroids

A

skin atrophy
telangiectasia
folliculitis
delayed wound healing

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Clinical therapeutics (8 decks)

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