Week 8 Flashcards
Where does the TCA cycle and ETC occur?
In the mitochondria cristae
What are the final products of glycolysis?
ATP, CO2, H20
What is the purpose of NADH and FADH?
They are electron carriers
What does the electron trasport chain do?
The ETC synthesises ATP from electron arriers with the presence of O2
What is NADH equivalent to in ATP’s?
2.5 ATP
What is FADH equivalent to in ATP’s?
1.5 ATP
Why does energy production occur through a large number of steps?
Occurs through several steps (e.g. glycolysis, TCA, ETC) becuase if it was just all at once it would be too exogernic and just heat us up.
What does Rotenone do>
It inhibits the first step of ETC so electrons don’t come off. Inhibits NADH2 oxidation.
How does the ETC warm the body?
Shivering, muscle contractions that pormote ATP hydrolysis - increases electron flow through ETC, and generates heat.
What happens when there is no oxygen present?
Mitochondria won’t function
Lactic acid formation
Alcoholic fermentation
What does pyruvate dehydrogenase do?
Converts pyruvate to Acetyl CoA - moves electrons
How is pyruvate dehydrogenase regulated?
Activated by F16P and inhibited by Acetyl-coA and NADH
What does the TCA cycle produce?
2x Pyruvate
2xGTP, 8xNADH, 2xFADH
What are the entry and exit points of the TCA cycle: consider the anaplerotic reactions?
Entry: Acety CoA, Oxaloactetate, Succyl CoA, Alpha ketogluterate
Exit: Malate, Oxaloacetate, Citrate, Succyl CoA, Alpha Ketogluterate
How is glucose metabolism connected to the TCA cycle?
The products of glycolysis enter the TCA cycle when oxygen is available go on to produce further energy.
