Week 7: Lymph Flow

Question 1

Lymph is a product of _____ and is important in _____

Answer 1

fluid exchange

maintatining the local and systemic fluid balance

Question 2

What is the rate of lymph production?

Answer 2

120 mL/hour

Question 3

The negative interstitial pressure (Pif) results from..?

Answer 3

the expansion tendency of charged proteoglycan filaments

Question 4

What forms the gel phase?

Answer 4

water molecules trapped by the proteoglycan mesh

Question 5

Bulk flow is possible through what phase?

Answer 5

sol phase (free fluid)

Question 6

Filtration load ____ interstitial fluid pressure

Answer 6

↑

Question 7

What is the process of filtration load?

Answer 7

• one part of the fluid entering is taken up by the gel
  
  • ​undergoes swelling
• with ↑ filtration load, ↑ larger part remains in free fluid form, ↑ size of sol phase​

once the gel has reached its maximum swelling, free fluid will accumulate and this causes tissue edema

Question 8

Draw the lymp capillary

Answer 8

Question 9

What causes tissue edema?

Answer 9

• ↑ capillary hydrostatic pressure
• ↑ capillary permeability
• ↓ capillary colloid osmotic pressure

Question 10

What are factors acting against tissue edema formatin?

Answer 10

• negative Pif
• lymph flow
• protein removal from the interstitium by lymph flow

Question 11

What are the causes of lymphedema?

Answer 11

• obstruction of lymph vessels by
  
  • toumor
  • parasites
  • others

Question 12

Draw the graph of lymph flow

Answer 12