Week 7 - Lecture 1 - Function and Regulation of Hormones Flashcards
Characteristics of hormones
chemicals with various structure, from simple to complex
formed originally in tissues or organs which affect the growth and/or function of other target tissue or organs (or in some case secretory tissue)
7 regulatory functions of hormones
- energy metabolism
- growth and development
- muscle and fat distribution
- fluid and electrolyte balance
- sexual maturation
- reproduction
- stress response
Features common to all hormones : control
hormone synthesis and release is controlled by tissues and organs
the hypothalamic-pituitary axis in the brain is an important control centre for many hormones
Features common to all hormones : patterns
hormones exhibit predictable patterns of
- secretion
- metabolism
- elimination
features common to all hormones : feedback
hormones listen and adjust based on negative or positive feedback loops
features common to all hormones : action
hormones exhibit two primary functions
- to act on target organs to achieve an effect or
- to act on glands to produce another hormone
features common to all hormones : receptor binding
to exert an effect, hormones must locate and attach onto target tissues
The hypothalamic - pituitary axis
pituitary gland (hypophysis) has two major lobes
posterior pituitary
- neural tissue
anterior pituitary (Adenohypophysis) -glandular tissue
The hypothalamic-pituitary axis 2
the hypothalamus responds to various stimuli (neurotransmitters and stressors) to produce the following hormones to transport to the pituitary:
- hormones that act on the anterior pituitary lobe
- prolactin
releasing hormones
- growth hormone-releasing hormone (GHRH)
- Thyrotropin-releasing hormone (TRH)
- Corticotropin - releasing hormone (CRH)
- Gonadotropin-releasing hormone
inhibiting hormones
- somatostatin (inhibits growth hormone and thyroid stimulating hormones)
- Dopamine (inhibits prolactin )
- Hormones that act on the posterior pituitary lobes:
Antidiuretic hormone (ADH)
Oxytocin
posterior pituitary
downgrowth of hypothalamic neural tissue
neural connection to hypothalamus (hypothalamic- hypophyseal tract)
Nuclei of hypothalamus synthesise neurohormones oxytocin and antidiuretic hormone (ADH)
Neurohormones are transported to posterior pituitary for release into the blood stream
Anterior lobe
Originates as outpocketing of oral mucosa
vascular connection to hypothalamus - hypophyseal portal system primary capillary plexus hypophyseal portal veins secondary capillary plexus
carries releasing and inhibiting hormones to anterior pituitary to regulate hormone secretion
Anterior Pituitary hormone action 1
the hypothalamus produces the hormone
the hormone travels to the anterior pituitary
the hormone is released unchanged into the circulation
example - prolactin
anterior pituitary hormone action 2
the hypothalamus produces a releasing hormone
the releasing hormone travels to and acts upon the anterior pituitary
the pituitary is stimulated to produce and release a different hormone into the circulation
example : growth hormone
anterior pituitary hormone action 3
the hypothalamus produces a releasing hormone
the anterior pituitary is activated to release a stimulating hormone
the stimulating hormone acts on the gland to produce and secrete a final hormone that tis released into the circulation
example : thyroid hormone