Week 7 - Lecture 1 - Function and Regulation of Hormones Flashcards

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1
Q

Characteristics of hormones

A

chemicals with various structure, from simple to complex

formed originally in tissues or organs which affect the growth and/or function of other target tissue or organs (or in some case secretory tissue)

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2
Q

7 regulatory functions of hormones

A
  1. energy metabolism
  2. growth and development
  3. muscle and fat distribution
  4. fluid and electrolyte balance
  5. sexual maturation
  6. reproduction
  7. stress response
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3
Q

Features common to all hormones : control

A

hormone synthesis and release is controlled by tissues and organs

the hypothalamic-pituitary axis in the brain is an important control centre for many hormones

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4
Q

Features common to all hormones : patterns

A

hormones exhibit predictable patterns of

  • secretion
  • metabolism
  • elimination
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5
Q

features common to all hormones : feedback

A

hormones listen and adjust based on negative or positive feedback loops

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6
Q

features common to all hormones : action

A

hormones exhibit two primary functions

  • to act on target organs to achieve an effect or
  • to act on glands to produce another hormone
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7
Q

features common to all hormones : receptor binding

A

to exert an effect, hormones must locate and attach onto target tissues

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8
Q

The hypothalamic - pituitary axis

A

pituitary gland (hypophysis) has two major lobes

posterior pituitary
- neural tissue

anterior pituitary (Adenohypophysis) 
-glandular tissue
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9
Q

The hypothalamic-pituitary axis 2

A

the hypothalamus responds to various stimuli (neurotransmitters and stressors) to produce the following hormones to transport to the pituitary:

  1. hormones that act on the anterior pituitary lobe
    - prolactin

releasing hormones

  • growth hormone-releasing hormone (GHRH)
  • Thyrotropin-releasing hormone (TRH)
  • Corticotropin - releasing hormone (CRH)
  • Gonadotropin-releasing hormone

inhibiting hormones

  • somatostatin (inhibits growth hormone and thyroid stimulating hormones)
  • Dopamine (inhibits prolactin )
  1. Hormones that act on the posterior pituitary lobes:
    Antidiuretic hormone (ADH)
    Oxytocin
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10
Q

posterior pituitary

A

downgrowth of hypothalamic neural tissue

neural connection to hypothalamus (hypothalamic- hypophyseal tract)

Nuclei of hypothalamus synthesise neurohormones oxytocin and antidiuretic hormone (ADH)

Neurohormones are transported to posterior pituitary for release into the blood stream

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11
Q

Anterior lobe

A

Originates as outpocketing of oral mucosa

vascular connection to hypothalamus 
- hypophyseal portal system 
 primary capillary plexus 
 hypophyseal portal veins 
 secondary capillary plexus 

carries releasing and inhibiting hormones to anterior pituitary to regulate hormone secretion

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12
Q

Anterior Pituitary hormone action 1

A

the hypothalamus produces the hormone

the hormone travels to the anterior pituitary

the hormone is released unchanged into the circulation

example - prolactin

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13
Q

anterior pituitary hormone action 2

A

the hypothalamus produces a releasing hormone

the releasing hormone travels to and acts upon the anterior pituitary

the pituitary is stimulated to produce and release a different hormone into the circulation

example : growth hormone

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14
Q

anterior pituitary hormone action 3

A

the hypothalamus produces a releasing hormone

the anterior pituitary is activated to release a stimulating hormone

the stimulating hormone acts on the gland to produce and secrete a final hormone that tis released into the circulation

example : thyroid hormone

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