Week 6: Pharmacology Flashcards
The study of the biological effects of chemicals
Pharmacology
___ deals with drugs effects on the body and the body’s response to drugs
Brach of pharmacology that uses drugs to prevent, treat, and diagnose disease.
Clinical pharmacology (pharmacotherapeutics)
Nurses monitor for _____ (what drug is susposed to do) and ___ (what the drug shouldn’t do)
Therapeutic effects
Adverse effects
Drug evaluation
Preclinical trails
Animals
Drug evaluation
Phase 1
Healthy humans
Drug evaluation
Phase 2
Target patients
Drug evaluation
Phase 3
Clinical setting
Drug evaluation
Phase 4
Continual evaluation
Drug names
N-(4-Hydroxyphenyl) acetamide
Acetaminophen
Tylenol
Chemical Name
Generic Name
Trade Name
U.S. Food and Drug Administration
Assigns drugs to a category of
Nonprescription
Prescription
Prescription can be divided into 2 more catagories
Controlled / Uncontrolled
How many schedules are there for controlled drugs
Which has no medical use in the US
5
Schedule 1 has no medical use in the US
_____ therapy is used with conventional/ tradicional medicine
Complementary therapy (integrative medicine)
______ is used instead of traditional/ conventional medicine
Alternative
_____ are substances that cause abnormal development of the fetus
Teratogens
When are fetuses most susceptible to teratogenic effects
1st trimester
How the drug affects the body
Replace / substitute for missing chemicals
Increase or Decrease cellular activity
Interfer with the functioning of foreign cells
Pharmacodynamics
How the body acts on drugs
Main processes involved are
Absorption
Distribution
Metabolism
Excretion
Pharmacokinetics
Pharmacodynamics (how drugs affect the body)
Ability to only attack foreign cells
(Penicillin)
Selective Toxicity
Pharmacodynamics (how drugs affect the body)
Interfer with enzyme systems that act as a catalyst for chemical reactions
(Lisinopril)
Drug-enzyme interactions
Pharmacodynamics (how drugs affect the body)
Receptor sites
Agonists (Morphine or Naloxone)
Antagonist (Morphine or Naloxone)
Agonist = Morphine
Antagonist = Naloxone
Pharmacokinetics (what the body does to the drugs)
_____ is the amount of drug needed to cause a therapeutic effect
Critical concentration
Drug dissolves in GI tract to be absorbed
Tabs and capsules will dissolve in the stomach and esophagus
______ do not dissolve until they reach the Alkaline small intestine
This process describes the _____ Phase
Enteric coated
Pharmaceutic Phase
Pharmacokinetics (what the body does to the drugs)
___ is moving a drug into the body for circulation
Absorption
Pharmacokinetics (what the body does to the drugs)
____ involves the movement of a drug to the body’s tissues
Factors that affect are
Circulation
Cell membrane
Plasma protein binding
Distribution
To cross the blood brain barrier a drug must be _____ soluble
Lipid
Aka biotransformation
Process by which th3 body changes a drug to a less active form that can be excreted
Metabolism
EC, ER, SR, XL are all long lasting drugs and examples of ____ coated
Enteric
Liver uses _____ enzyme to alter drugs and start metabolism
P-450
Nicotine, Alcohol, and Gluticosteroids all (Induce / Inhibit) P-450 enzyme
Speeds up the metabolism
Patient will not receive full effect of medication
Induce
Aminodarone
Ketoconazole
Both (Induce/ Inhibit) cytochrome P-450 metabolism
This can allow the drug to build up to toxic levels
Inhibit
First-pass effect refers to
The ability of the liver to make drugs less powerful
Drugs are metabolized by _____
Excreted by ____
Liver
Kidneys
The amount of time it takes the level of a drug in your system to be cut in half.
Half-life
Drugs with a (short / long) half-life need to be administrated more frequently
Drugs with a (short/long) half-life need to be administrated less frequently
Short = more frequently
Long = less frequently
A (large / small) therapeutic index is safer
Large
Levels important when discussing therapeutic index
_____ highest concentration in blood
______ lowest concentration of drug in blood
Peak
Trough
Expected and predictable effects that result at therapeutic dosage
Benadryl makes you sleepy
Opiods cause constipation
Antibiotics cause nausea
Side effects
Undesirable, inadvertent, unexpected and sometimes sever response to medications
Lasix causes hearing loss
Antibiotics allow for a Cdiff infection
Adverse effects
Conditions clients have that make it unsafe to recieve medications
Contraindications
Adverse effects can be divided into primary and secondary effects not related to the therapeutic effect
_____ blood thinner causes excessive GI bleeding.
_____ dermatological reaction because drug can deposit in skin
Primary
Secondary
Toxic reactions are likely to occur due to this organ not functioning properly
Kidney
Angioedema is…
Swelling of eyes, lips, tongue
Rapid onset
Dyspnea
Tingling
Itching
Low BP
Tachycardia
Are symptoms of
Anaphylaxis
Nurse implications for administration of drugs includes
Monitor for therapeutic ___
Response
Beta blockers
Suffix
Used for
Before giving check….
Side Effects
Suffix - olol
Used for HTN, HF, Irregular heart rhythm
SE:
Lightheadedness
Bradycardia
Hypotension
Fatigue
Suffix - olol
Used for HTN, HF, Irregular heart rhythm
SE:
Lightheadedness
Bradycardia
Hypotension
Fatigue
Beta blockers
Prevents conversion of angiotensin 1 to angiotensin 2.
Which causes vasodilation
Suffix - pril
Ace inhibitor
Ace Inhibitor
Suffix -
Use
Suffix - pril
Use: prevention of conversion of angiotensin 1 to angiotensin 2 (which causes vasodilation)
Angiotensin II
Receptor
Blockers (ARB)
SUFFIX -
Treats
TEACH
Suffix: SARTAN (irbesartan, valsartan, losartan and candesartan)
Treats: to treat high blood pressure and heart failure.
Teach: slow posistion changes
Notify provider if angioedema
Calcium channel blockers
Suffix - Plus 2 exceptions
Therapeutic effect
Side Effects
Suffix - Dipine
Plus, verapamil & diltiazem
Therapeutic effect: Lowe’s contractility & conductivity of the heart.
Lowers demand for oxygen
Side effects:
Lower BP
Bradycardia
Precipitate AV block
Headache
Peripheral Edema
Suffix - Dipine
Plus, verapamil & diltiazem
Therapeutic effect: Lowe’s contractility & conductivity of the heart.
Lowers demand for oxygen
Side effects:
Lower BP
Bradycardia
Precipitate AV block
Headache
Peripheral Edema
Calcium Channel blockers
High Loop Diuretics
Suffix - ide
Before giving check
Clinical uses:
Side effects:
Suffix -ide
Check BP / K+ before giving
Clinical uses:
Heart Failure
Hypertension
Edema
Side effects:
Hyponatremia
Hypokalemia
Hypomagnesium
Ototoxicity (hearing or balance problem due to medication)
Suffix -ide
Check BP / K+ before giving
Clinical uses:
Heart Failure
Hypertension
Edema
Side effects:
Hyponatremia
Hypokalemia
Hypomagnesium
Ototoxicity (hearing or balance problem due to medication)
High loop diuretics
Loop diuretics include
ET is Fabulous
Erthacrynic acid
Torasemide
Furosemide
Azosemide
Bumetanide
Potassium Sparring Diuretics
Names: PASTE
Potassium sparring diuretics
Amilorde
Spironolactone
Triamterene
Epleronome
Potassium Sparring Diuretics
Used to treat:
Check ___ before giving
What is their function
Treat: Edema CHF
Check K & BP
Function: gets rid of sodium and water. Blocks Aldosterone in the kidney
Ace inhibitor Adverse Effects (2)
Hyperkalemia/ Angioedema
ACE & ARBS are similar except by this side effect
ACE has a dry cough
Adverse effect for ACE INHIBITOR
Hyperkalemia/ angioedema
Name Calcium channel blockers
(Are Very Nice Drugs)
Amlodipine
Verapamil
Nifedepine
Diltiazem
Loop diuretics will affect this electrolyte the most
K+ Potassium
Potassium Sparring Diuretics can lead to (hypo / Hyperkalemia)
Hyperkalemia