Week 6

Question 1

What is the most common source of breast cancer?

Answer 1

• duct system - 90%

- lobule/terminal duct - 5-10%

Question 2

Of DCIS and LCIS, which is more likely to reoccur over 15 years later?

Answer 2

LCIS

Question 3

What is the most common breast carcinoma? second?

Answer 3

1st - ductal or lobular carcinoma-in-situ

2nd - atypical ductal or lobular hyperplasia

Question 4

What type of drugs are Dutasteride and Finasteride?

Answer 4

5-alpha reductase inhibitors

Question 5

What drug blocks 17 alpha-hydroxylase/ C17,20 lyase (CYP17 inhibitor)?

Answer 5

Abiraterone acetate

Question 6

What type of drug ends in =ozole? (plus 2 exceptions)

Answer 6

Aromatase inhibitors (Aminoglutethimide, Anastrozole, Letrozole, Exemastane)

Question 7

Which cancer drug blocks cholesterol to pregnenolone (results in adrenal insufficiency?

Answer 7

Aminoglutethamide

-can also result in bone marrow suppression from increased cortisol levels

Question 8

What is the unique toxicity for Anastrozole, Letrozole, and Exemastane?

Answer 8

Polyarthralgia

Question 9

Which drugs for prostate cancer aren’t given long term due to hepatotoxicity?

Answer 9

anti-androgens (Bicalutamide, Flutamide, Nilutamide)

Question 10

What is the role of Finasteride?

Answer 10

reduces dihydrotestosterone production