Week 5 Neuromuscular Blocking Agents

Question 1

Succinylcholine
ED95 Dose & Intubation Dose
Onset of Action
Duration of Action

Answer 1

ED95 Dose: 0.3mg/kg
Intubation Dose: 0.6-1mg/kg-> Onset: 45-60secs
DOA: 8-15 minutes

Question 2

Cisatracurium
ED95 Dose & Intubation Dose
Onset of Action
Duration of Action

Answer 2

ED95 Dose: 0.05mg/kg-> Onset: 3-5 mins
DOA: 20-35mins
Intubation Dose: 0.1-0.2mg/kg
DOA: 45-70mins

Question 3

Vecuronium
ED95 Dose & Intubation Dose
Onset of Action
Duration of Action

Answer 3

ED95 Dose: 0.03-0.05mg/kg
Intubation Dose: 0.1-0.2mg/kg-> Onset: 2-2.5mins
DOA: 25-40mins

Question 4

Rocuronium

ED95 Dose, Intubation Dose, & High-Dose

Answer 4

ED95 Dose: 0.3mg/kg-> Onset: 3-5mins
DOA: 20-30mins
Intubation Dose: 0.6mg/kg-> Onset: 1.5-2mins
DOA: 25-45mins
High Dose: 1.2mg/kg-> Onset: 60secs
DOA: 60-120mins

Question 5

Suggamadex
Works on which NMBs?
"Deep" Block (NO Twitches) Dose & Onset
"Moderate" Block (At least 2 Twitches) Dose & Onset
Max Dose

Answer 5

-curoniums
“Deep” Dose: 4-16mg/kg-> Onset: 2-4mins to 90% TOF
“Moderate” Dose: 2mg/kg-> Onset: 1-2mins to 90% TOF
Max Dose: NONE!

Question 6

What drug is administered with Neostigmine?

What drug is administered with Edrophonium?

Answer 6

Neostigmine-Glycopyrrolate

Edrophonim-Atropine

Question 7

Neostigmine
Dose
Onset of Action
Duration of Action
Total MAX Dose

Answer 7

0.04-0.08mg/kg (with Glyco 0.2mg/mg Neostigmine)
Onset: 5 mins
DOA: 60+ mins
Total Max Dose: 5mg

Question 8

Edrophonium
Dose
Onset of Action

Answer 8

0.5-1.0mg/kg (with Atropine 0.01mg/mg Edrophonium)

Onset: 45-120 secs

Question 9

Pyridostigmine
Dose
Onset of Action
Duration of Action

Answer 9

0.1-0.25mg/kg (with Glyco 0.05mg/mg Pyridostigmine)
Onset: 10-15mins
DOA: 120+ mins

Question 10

Dantrolene Sodium
Initial Dose & Repeat Dose
Total Max Dose

Answer 10

Initial Dose: 2mg/kg
Repeat Dose: 2mg/kg
Total Max Dose: 10mg/kg