Week 3 IV Anesthetic Agents Flashcards
Droperidol
Use & Dose
Anti-Emetic (currently)
Dose: 0.625-1.25mg
Midazolam
Induction Dose
Elimination Half-Life
Is it >80% Protein Bound?
Induction Dose: 0.1-0.3mg/kg
Elimination Half-Life: 2-2.5 hours
Yes, 98% Protein Bound
Lorazepam
Use & Dose
Elimination Half-Life
Is it >80% Protein Bound?
Pre-medicating Dose: 0.5-2mg
Elimination Half-Life: 10-20 hours
Yes, 91% Protein Bound
Diazepam
Induction Dose
Elimination Half-Life
Is it >80% Protein Bound?
NOT used for Inductions or Pre-medicating for Surgery
Elimination Half-Life: 20-50 hours
Yes, 98% Protein Bound
Methohexital
Induction Dose
Elimination Half-Life
Is it >80% Protein Bound?
Induction Dose: 1-1.5mg/kg
Elimination Half-Time: 2-6 hours
NO, only 73% Protein Bound
ThioPental
Induction Dose
Elimination Half-Life
Is it >80% Protein Bound?
Induction Dose: 3-5mg/kg
Elimination Half-Life: 7-17 hours
Yes, 83% Protein Bound
Dexmedetomidine Pre-medication Dose & Infusion Dose Elimination Half-Life Clearance Is it >80% Protein Bound?
Pre-Medicate Dose: 0.33-0.67mcg/kg 15mins before surgery
Infusion Dose: 0.7mcg/kg/min to keep BIS 70-80
Elimination Half-Life: 2-3 hours
Yes, 90% Protein Bound
Ketamine
Induction Dose
Elimination Half-Life
Is it >80% Protein Bound?
Induction Dose: 1-3mg/kg
Elimination Half-Life: 2-3 hours
NO, only 12% Protein Bound
Etomidate
Induction Dose
Elimination Half-Life
Is it >80% Protein Bound?
Induction Dose: 0.2-0.4mg/kg
Elimination Half-Life: 3-5 hours
NO, only 75% Protein Bound
Propofol
Induction Dose & Infusion Dose
Elimination Half-Life
Is it >80% Protein Bound?
Induction Dose: 1.5-2.5mg/kg
Infusion Dose: 25-100mcg/kg/min for Sedation
100-300mcg/kg/min for Anesthesia (TIVA)
Elimination Half-Life: 4-7 hours
Yes, 95-99% Protein Bound
Effects of Droperidol on:
SBP, SVR, HR, & RR
Decreased SBP & SVR
NO change in HR & RR
Effects of Benzodiazepines on:
SBP, SVR, HR, Respiratory, CBF, ICP, CMRO2
NO change in SBP, SVR, or HR
Decreased Respiratory, CBF, ICP, & CMRO2
Effects of ThioPental on:
SBP, SVR, HR, Respiratory, CBF, ICP, CMRO2
Decreased SBP, SVR, Respiratory, CBF, ICP, & CMRO2
Increased HR
Effects of Dexmedetomidine on:
SBP, SVR, HR, Respiratory, Neuro
Decreased SBP, SVR, & HR
Minimal decrease in Respiratory
Effects of Ketamine on:
SBP, SVR, HR, Respiratory, CBF, ICP, CMRO2
Increases in EVERYTHING except…
NO change in Respiratory