Week 3 IV Anesthetic Agents

Question 1

Droperidol

Use & Dose

Answer 1

Anti-Emetic (currently)

Dose: 0.625-1.25mg

Question 2

Midazolam
Induction Dose
Elimination Half-Life
Is it >80% Protein Bound?

Answer 2

Induction Dose: 0.1-0.3mg/kg
Elimination Half-Life: 2-2.5 hours
Yes, 98% Protein Bound

Question 3

Lorazepam
Use & Dose
Elimination Half-Life
Is it >80% Protein Bound?

Answer 3

Pre-medicating Dose: 0.5-2mg
Elimination Half-Life: 10-20 hours
Yes, 91% Protein Bound

Question 4

Diazepam
Induction Dose
Elimination Half-Life
Is it >80% Protein Bound?

Answer 4

NOT used for Inductions or Pre-medicating for Surgery
Elimination Half-Life: 20-50 hours
Yes, 98% Protein Bound

Question 5

Methohexital
Induction Dose
Elimination Half-Life
Is it >80% Protein Bound?

Answer 5

Induction Dose: 1-1.5mg/kg
Elimination Half-Time: 2-6 hours
NO, only 73% Protein Bound

Question 6

ThioPental
Induction Dose
Elimination Half-Life
Is it >80% Protein Bound?

Answer 6

Induction Dose: 3-5mg/kg
Elimination Half-Life: 7-17 hours
Yes, 83% Protein Bound

Question 7

Dexmedetomidine
Pre-medication Dose & Infusion Dose
Elimination Half-Life
Clearance
Is it >80% Protein Bound?

Answer 7

Pre-Medicate Dose: 0.33-0.67mcg/kg 15mins before surgery
Infusion Dose: 0.7mcg/kg/min to keep BIS 70-80
Elimination Half-Life: 2-3 hours
Yes, 90% Protein Bound

Question 8

Ketamine
Induction Dose
Elimination Half-Life
Is it >80% Protein Bound?

Answer 8

Induction Dose: 1-3mg/kg
Elimination Half-Life: 2-3 hours
NO, only 12% Protein Bound

Question 9

Etomidate
Induction Dose
Elimination Half-Life
Is it >80% Protein Bound?

Answer 9

Induction Dose: 0.2-0.4mg/kg
Elimination Half-Life: 3-5 hours
NO, only 75% Protein Bound

Question 10

Propofol
Induction Dose & Infusion Dose
Elimination Half-Life
Is it >80% Protein Bound?

Answer 10

Induction Dose: 1.5-2.5mg/kg
Infusion Dose: 25-100mcg/kg/min for Sedation
100-300mcg/kg/min for Anesthesia (TIVA)
Elimination Half-Life: 4-7 hours
Yes, 95-99% Protein Bound

Question 11

Effects of Droperidol on:

SBP, SVR, HR, & RR

Answer 11

Decreased SBP & SVR

NO change in HR & RR

Question 12

Effects of Benzodiazepines on:

SBP, SVR, HR, Respiratory, CBF, ICP, CMRO2

Answer 12

NO change in SBP, SVR, or HR

Decreased Respiratory, CBF, ICP, & CMRO2

Question 13

Effects of ThioPental on:

SBP, SVR, HR, Respiratory, CBF, ICP, CMRO2

Answer 13

Decreased SBP, SVR, Respiratory, CBF, ICP, & CMRO2

Increased HR

Question 14

Effects of Dexmedetomidine on:

SBP, SVR, HR, Respiratory, Neuro

Answer 14

Decreased SBP, SVR, & HR

Minimal decrease in Respiratory

Question 15

Effects of Ketamine on:

SBP, SVR, HR, Respiratory, CBF, ICP, CMRO2

Answer 15

Increases in EVERYTHING except…

NO change in Respiratory

Question 16

Effects of Etomidate on:

SBP, SVR, HR, Respiratory, CBF, ICP, CMRO2

Answer 16

NO change in SBP, SVR, or HR
Minimal decrease in Respiratory
Decreased CBF, ICP, & CMRO2

Question 17

Effects of Propofol on:

SBP, SVR, HR, Respiratory, CBF, ICP, CMRO2

Answer 17

Decreased SBP, SVR, Respiratory, CBF, ICP, & CMRO2

NO change in HR

Question 18

Which of the following IV Induction Agents produce Analgesia?
Droperidol
Midazolam
ThioPental
Dexmedetomidine
Ketamine
Etomidate
Propofol

Answer 18

Dexmedetomidine

Ketamine

Question 19

Besides Anesthesia, what other properties does Propofol have?

Answer 19

Anti-emetic, Anti-pruritic, Anti-convulsant

Question 20

Flumazenil
Dose
Onset of Action
Duration of Action
Max Dose in 1 Hour

Answer 20

Dose: 0.2mg q45secs
Onset of Action: 30 seconds-2 minutes
DOA: 30-60 minutes
Max Dose: 3mg/hour

Question 21

When would Flumazenil be contraindicated?

Answer 21

In Seizure patient’s on Neuroleptic Drugs