WEEK 5 (CHAPTER 6) Flashcards
- Defined as a dosage form composed of solid or mixture of solids reduced to a finely divided state and intended for internal or external use.
- enable a primary care provider to alter the quantity of each medication for each
dose. (Used in clinical studies of drug preparation) - For infants and young children. You can mix with formula or sprinkle with applesauce
- provide a rapid onset of action
Medicated powders is limited but the use of powdered substances in the formation of other dosage form is extensive
Powder
agglomerates of powdered materials
Granules
Physicochemical considerations:
- Particle size
- Particle shape
- Particle density
- Electrostatic charges
- Adhering/repelling properties
dimension of solid
Particles of uniform size are blended easier
Particle size
Spherical particles are easier to mix and transported easily from an area of high conc to low conc
Needle-shaped and cubic-shaped particles do not slide over each other as easily and tend to clog or stick together
Particle shape
- heavy particles sink while light particles tend to rise
Particle density
- Static electricity hamper blending
- Overcome by humidification of the work area.
- Add sodium lauryl sulfate to neutralize the charges.
Electrostatic charges
-Some particles tend to adhere or repel each other
- The faster they are individually diluted with an inert substance or nonreactive material in the formulation, the easier it is to blend them
Adhering/repelling properties
-all particles pass through sieve no. 8 and not more than 20% pass through sieve number 60.
Very coarse (No. 8)
- All particles pass through sieve no. 20, and not more than 40% pass through sieve no. 60
Coarse (No. 20)
- All particles pass through sieve no. 40 and not more than 40% pass through sieve no. 80
Moderately coarse (No. 40)
All particles pass through sieve no. 60 and not more than 40% pass through sieve no. 100
Fine (No. 60)
Particles are passed through mechanical shaking through a series of sieves of known and successively
smaller size
Sieving
All particles pass through sieve no. 80. There is no limit to greater fineness
Very fine (No. 80)
Sample particles are sized through the use of calibrated grid background
Microscopy