Week 5 - Cementum Flashcards
What is cementum made of?
Nearly 50/50 organic/inorganic split
What are the organic components of cementum?
- Type I collagen (intrinsic and Sharpey’s fibers)
- Proteoglycans
- Glycosaminoglycans
- Phosphoproteins
What does cementum provide an attachment for?
The PDL through sharpey’s fibers
How does cementum provide compensation for occlusal wear?
Through continuous apical apposition
- as the tooth wears down, reparative dentin lays down to stabilize
What may cementum participate in?
Repair of root fracture
What is the origin of cementum?
Ectomesenchymal
What is the quantity of mineral comparison of cementum, bone and dentin?
Cementum contains less mineral than both bone and dentin
Is cementum vascular?
Avascular, not innervated, and contains no haversion or volkmann’s canals
Where is cementum the thinnest?
At the CEJ (30-50 µm)
and progressively increases in thickness to 90-150 µm at mid-root to 150-300 µm at the apex
What are cementoblasts responsible for?
secretion of the organic matrix of cementum
What are cementoblasts derived from?
undifferentiate mesenchymal cells that originate in the proximal (inner) zone of the dental follicle
What are all cells in the dental follicle derived from?
Ectomesenchyme (neural crest cells)
How is differentiation initiated with?
disruption of Hertwig’s
epithelial root sheath, allowing the undifferentiated mesenchymal cells to make contact with the adjacent dentin
What induces differentiation process?
Dentin matrix growth factors (BMP, FGF, DMP)
What does hertwig’s root sheath contain for the mesenchymal cells to enter?
Perforations that make contact with growth factors and come from pulp through holes
What are histological features of cementum?
- Depositional lines
- Reversal lines
- Cementoblasts
- Cementocytes
- Lacunae
- Canaliculi
- Sharpey’s fibers (PDL)
What do depositional and reversal lines indicate?
Incremental growth, and run longitudinally within the cementum