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IHO week 5 > Week 5 buzzwords > Flashcards

Week 5 buzzwords Flashcards

1
Q

Intracellular organisms

response?

A

CD8’s

NK’s

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2
Q

Extracellular organisms

response?

A

Humoral

Ig’s

Complement

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3
Q

no Treg’s

A

IPEX

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4
Q

Autocrine cytokine for Treg?

A

IL-35

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5
Q

Cytokine

decreases Th1’s

B-cell class switch

A

IL-10

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6
Q

T-cell surface receptor

binds APC CD80/86

causes cell cycle arrest of T-cell

A

CD152 (CTLA4)

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7
Q

over production of thyroid hormones

A

Grave’s disease

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8
Q

IL-12

A

makes Th1’s

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9
Q

IL-4

A

makes Th2’s

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10
Q 
IL-4
IL-5
IL-9
IL-10
IL-13

(collectively)

A

Th2 cytokines

IgG1 IgE isotype switching

Mucosal immunity

stimulate mast cells and eosinophils

IgA synthesis

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11
Q

IFN-y
TNF-B
IL-2

(collectively)

A

Th1 cytokines

activate Mac’s (M1/angry)

Ig dependent cytotoxicity

delated hypersensitivity

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12
Q

Ig dependent B-cell supression

A

Ig blocking

receptor crosslinking

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13
Q

Ig dependent B-cell augmentation

A

FDC

CR2

IgM

C3d

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14
Q

CCR7

A

T&B activation?

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15
Q

AIRE

A

APECED

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16
Q

ANAs

A

SLE

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17
Q

Antibodies for:

Smith (Sm) antigen

dsDNA

A

SLE

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18
Q

anti-phospholipid anitbodies

A

SLE

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19
Q

SOAP BRAIN MD

A

SLE

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20
Q

“wire loop” lesions

A

SLE

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21
Q

SS-A

HLA-DR3

A

Subacute Cutaneous LE

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22
Q

CCPs

A

RA

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23
Q

dry eyes

dry mouth

A

Sjogren Syndrome

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24
Q

SS-A

SS-B

A

Sjogren Syndrome

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25
Q

MALT lymphoma

A

Sjogren Syndrome

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26
Q

perivascular FIBROSIS

A

Systemic Sclerosis

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27
Q

Scl-70 (DNA topo 1)

A

Systemic Sclerosis

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28
Q

anti-centromere antibodies

A

CREST syndrome

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29
Q

Raynaud’s

A

Systemic Sclerosis

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30
Q

skin rash + muscle weakness

A

Dermatomyositis

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31
Q

must screen for underlying malignancy

A

Dermatomyositis

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32
Q

anti-Jo1

muscle weakness

NO skin involvement

A

Polymyositis

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33
Q

anti-U1-RNP

A

Multiple Connective Tissue Disease

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34
Q

no B-cells

A

X-linked Aggammaglobulinemia

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35
Q

Btk

A

X-linked Aggammaglobulinemia

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36
Q

B-cells

NO plasma cells

A

Common Variable Immunodeficiency

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37
Q

low/no IgA

A

Isolated IgA deficiency

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38
Q

22q11

A

DiGeorge Syndrome

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39
Q

No thymus –> low T-cells

A

DiGeorge Syndrome

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40
Q

no CD40

low/no IgA, IgE, IgG

A

Hyper-IgM Syndrome

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41
Q

no Humoral immunity

no Cell-mediated immunity

A

SCID

42
Q

ADA deficiency

A

SCID

43
Q

Eczema

A

Wiskott-Aldrich Syndrome

44
Q

can’t eliminate EBV

SLAM protein

B-cell lymophoma

A

X-linked lymphoproliferative disorder

45
Q

defective phagosomes and/or lysosomes

A

Chediak-Higashi Syndrome

46
Q

CHS1/LYST

A

Chediak-Higashi Syndrome

47
Q

giant granules in Leukocytes

A

Chediak-Higashi Syndrome

48
Q

Increased risk for encapsulated organism infx

A

Asplenia

49
Q

Pneumocystis jiroveci

A

T-cell defect (ie. HIV)

50
Q

Complement defect

A

Neisserial infx

51
Q

Granulocyte defect

A

Nocardia infx

52
Q

HLA-A,B,C

A

MHC I – all cells

53
Q

HLA-DR

A

MHC II – APCs only

54
Q

ABO

HLA

don’t match

A

Graft rejection!

55
Q

ABO incompatibility

preexisting HLA antibodies

A

Hyperacute rejection

56
Q

T-cell mediated graft rejection

A

Acute

57
Q

cell mediated + antibody mediated graft rejection

A

Chronic

58
Q

Congo red stain

A

amyloid

**looks green when polarized

59
Q

Alzheimer disease

A

Beta-amyloid protein

60
Q

Beta2-microglobulin

joint disease

A

Hemodialysis associated amyloidosis

61
Q

Calcineurin inhibitor

Cyp P450

NFAT

Tx to prevent transplant rejection

A

Cyclosporine

62
Q

FK506

blocks T-cell activation

TOXIC

A

Tacrolimus

63
Q

mTor binder

blocks G1-S phase

Cyp P450

A

Sirolimus

64
Q

Inhibits inosine monophosphate dehydrogenase

A

Mycophenolate

65
Q

Ig binds T-cells

Immunosupressor

A

anti-thymocyte globulin

66
Q

Ig binds CD3 on TCR

A

Muromonab-CD3

67
Q

Anti-CD25 (IL-2R)

two of them

A

Daclizumab

Basiliximab

68
Q

H1 antagonist

sedative

A

diphenhydramine

69
Q

H1 antagonist

less sedation

A

Chlorpheniramine

70
Q

Second gen H1 blockers (OTC)

A

Cetirizine

Loratidine

71
Q

Second gen H1 blocker (Rx)

A

Fexofenadine

72
Q

5-lipoxygenase blocker

A

Zileuton

73
Q

CysLTR1 blockers

A

Zafirlukast

Montelukast (one daily)

74
Q

Irreversablt COX 1 inhibitor

A

acetylsalicylate

75
Q

Short acting COX 1/2 inhibitor

A

Ibuprofen

76
Q

Long acting COX 1/2 inhibitor

A

Naproxen

77
Q

IV COX 1/2 pain reliver

A

Ketorolac

78
Q

Stongest COX 1/2 inhibitor

A

Indomethacin

79
Q

selective COX 2 inhibitor

A

celecoxib

80
Q

weak COX inhibitor

not much anti-inflammatory

A

acetaminophen

81
Q

inhibits kallikrein

A

C1INH

82
Q

AA –> leukotrienes

A

lipoxygenase

83
Q

AA –> PGs and TX

A

COX

84
Q

phospholipids –> AA

A

phospholipase A2

85
Q

LTB4

A

chemotaxis

86
Q

LTC4, D4, E4

A

bronchoconstriction

87
Q

Cys LTR1

A

LTC4
LTD4

bronchoconstriction

88
Q

Cys LTR2

A

LTC4
LTD4

endothelial cell and Mac activation

FIBROSIS

89
Q

B2 receptor + kinins

A

Hypotension (vasodilation)

90
Q

ACE

A

degrades bradykinin

91
Q

stimulates release of endogenous corticosteroids from adrenal medulla

A

ACTH

92
Q

Fexner-Wintersteiner Rosettes

A

Retinoblastoma

93
Q

Rb mutation –>

A

loss of E2F inhibition at G1-S checkpoint

94
Q

bilateral retinoblastoma presentation

A

inherited Rb1 muation

95
Q

unilateral retinoblastoma presentation

A

acquired Rb1 mutation

96
Q

impaired wound healing

bleeding gums

ecchymosis

A

vit C deficiency

97
Q

peroxisomes

kidney/liver

reduces H2O2 –> H2O

prevents Haber-Weiss rxn

A

Catalase

98
Q

superoxide –> H2O2 + O2

primary defense against oxidative stress

ALS

A

superoxide dismutase

99
Q

ROS from blood O2 reenters hypoxic cells

A

Ischemia-reperfusion injury

100
Q

genetic defect in NADPH oxidase

recurrent infx

catalase POSITIVE organisms

caeseous necrosis

A

Chronic Granulomatous disease

101
Q

CCR7

A

trafficking to lymph node

102
Q

foxP3

A

Tregs

IHO week 5 (8 decks)

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