Week 5 buzzwords Flashcards
1
Q
Intracellular organisms
response?
A
CD8’s
NK’s
2
Q
Extracellular organisms
response?
A
Humoral
Ig’s
Complement
3
Q
no Treg’s
A
IPEX
4
Q
Autocrine cytokine for Treg?
A
IL-35
5
Q
Cytokine
decreases Th1’s
B-cell class switch
A
IL-10
6
Q
T-cell surface receptor
binds APC CD80/86
causes cell cycle arrest of T-cell
A
CD152 (CTLA4)
7
Q
over production of thyroid hormones
A
Grave’s disease
8
Q
IL-12
A
makes Th1’s
9
Q
IL-4
A
makes Th2’s
10
Q
IL-4 IL-5 IL-9 IL-10 IL-13
(collectively)
A
Th2 cytokines
IgG1 IgE isotype switching
Mucosal immunity
stimulate mast cells and eosinophils
IgA synthesis
11
Q
IFN-y
TNF-B
IL-2
(collectively)
A
Th1 cytokines
activate Mac’s (M1/angry)
Ig dependent cytotoxicity
delated hypersensitivity
12
Q
Ig dependent B-cell supression
A
Ig blocking
receptor crosslinking
13
Q
Ig dependent B-cell augmentation
A
FDC
CR2
IgM
C3d
14
Q
CCR7
A
T&B activation?
15
Q
AIRE
A
APECED
16
Q
ANAs
A
SLE
17
Q
Antibodies for:
Smith (Sm) antigen
dsDNA
A
SLE
18
Q
anti-phospholipid anitbodies
A
SLE
19
Q
SOAP BRAIN MD
A
SLE
20
Q
“wire loop” lesions
A
SLE
21
Q
SS-A
HLA-DR3
A
Subacute Cutaneous LE
22
Q
CCPs
A
RA
23
Q
dry eyes
dry mouth
A
Sjogren Syndrome
24
Q
SS-A
SS-B
A
Sjogren Syndrome
25
MALT lymphoma
Sjogren Syndrome
26
perivascular FIBROSIS
Systemic Sclerosis
27
Scl-70 (DNA topo 1)
Systemic Sclerosis
28
anti-centromere antibodies
CREST syndrome
29
Raynaud's
Systemic Sclerosis
30
skin rash + muscle weakness
Dermatomyositis
31
must screen for underlying malignancy
Dermatomyositis
32
anti-Jo1
muscle weakness
NO skin involvement
Polymyositis
33
anti-U1-RNP
Multiple Connective Tissue Disease
34
no B-cells
X-linked Aggammaglobulinemia
35
Btk
X-linked Aggammaglobulinemia
36
B-cells
NO plasma cells
Common Variable Immunodeficiency
37
low/no IgA
Isolated IgA deficiency
38
22q11
DiGeorge Syndrome
39
No thymus --> low T-cells
DiGeorge Syndrome
40
no CD40
low/no IgA, IgE, IgG
Hyper-IgM Syndrome
41
no Humoral immunity
no Cell-mediated immunity
SCID
42
ADA deficiency
SCID
43
Eczema
Wiskott-Aldrich Syndrome
44
can't eliminate EBV
SLAM protein
B-cell lymophoma
X-linked lymphoproliferative disorder
45
defective phagosomes and/or lysosomes
Chediak-Higashi Syndrome
46
CHS1/LYST
Chediak-Higashi Syndrome
47
giant granules in Leukocytes
Chediak-Higashi Syndrome
48
Increased risk for encapsulated organism infx
Asplenia
49
Pneumocystis jiroveci
T-cell defect (ie. HIV)
50
Complement defect
Neisserial infx
51
Granulocyte defect
Nocardia infx
52
HLA-A,B,C
MHC I -- all cells
53
HLA-DR
MHC II -- APCs only
54
ABO
HLA
don't match
Graft rejection!
55
ABO incompatibility
preexisting HLA antibodies
Hyperacute rejection
56
T-cell mediated graft rejection
Acute
57
cell mediated + antibody mediated graft rejection
Chronic
58
Congo red stain
amyloid
**looks green when polarized
59
Alzheimer disease
Beta-amyloid protein
60
Beta2-microglobulin
joint disease
Hemodialysis associated amyloidosis
61
Calcineurin inhibitor
Cyp P450
NFAT
Tx to prevent transplant rejection
Cyclosporine
62
FK506
blocks T-cell activation
TOXIC
Tacrolimus
63
mTor binder
blocks G1-S phase
Cyp P450
Sirolimus
64
Inhibits inosine monophosphate dehydrogenase
Mycophenolate
65
Ig binds T-cells
Immunosupressor
anti-thymocyte globulin
66
Ig binds CD3 on TCR
Muromonab-CD3
67
Anti-CD25 (IL-2R)
| two of them
Daclizumab
Basiliximab
68
H1 antagonist
sedative
diphenhydramine
69
H1 antagonist
less sedation
Chlorpheniramine
70
Second gen H1 blockers (OTC)
Cetirizine
Loratidine
71
Second gen H1 blocker (Rx)
Fexofenadine
72
5-lipoxygenase blocker
Zileuton
73
CysLTR1 blockers
Zafirlukast
Montelukast (one daily)
74
Irreversablt COX 1 inhibitor
acetylsalicylate
75
Short acting COX 1/2 inhibitor
Ibuprofen
76
Long acting COX 1/2 inhibitor
Naproxen
77
IV COX 1/2 pain reliver
Ketorolac
78
Stongest COX 1/2 inhibitor
Indomethacin
79
selective COX 2 inhibitor
celecoxib
80
weak COX inhibitor
not much anti-inflammatory
acetaminophen
81
inhibits kallikrein
C1INH
82
AA --> leukotrienes
lipoxygenase
83
AA --> PGs and TX
COX
84
phospholipids --> AA
phospholipase A2
85
LTB4
chemotaxis
86
LTC4, D4, E4
bronchoconstriction
87
Cys LTR1
LTC4
LTD4
bronchoconstriction
88
Cys LTR2
LTC4
LTD4
endothelial cell and Mac activation
FIBROSIS
89
B2 receptor + kinins
Hypotension (vasodilation)
90
ACE
degrades bradykinin
91
stimulates release of endogenous corticosteroids from adrenal medulla
ACTH
92
Fexner-Wintersteiner Rosettes
Retinoblastoma
93
Rb mutation -->
loss of E2F inhibition at G1-S checkpoint
94
bilateral retinoblastoma presentation
inherited Rb1 muation
95
unilateral retinoblastoma presentation
acquired Rb1 mutation
96
impaired wound healing
bleeding gums
ecchymosis
vit C deficiency
97
peroxisomes
kidney/liver
reduces H2O2 --> H2O
prevents Haber-Weiss rxn
Catalase
98
superoxide --> H2O2 + O2
primary defense against oxidative stress
ALS
superoxide dismutase
99
ROS from blood O2 reenters hypoxic cells
Ischemia-reperfusion injury
100
genetic defect in NADPH oxidase
recurrent infx
catalase POSITIVE organisms
caeseous necrosis
Chronic Granulomatous disease
101
CCR7
trafficking to lymph node
102
foxP3
Tregs
