Regulation of the Immune Response Flashcards
Key molecules involved in tolerogenic DC:T-cell interactions:
CD152 (CTLA-4)
IL-10
TGF-B
What is meant by “tolerogenic”:
DC induction of clonal deletion or anergy of antigenic specific T-cells
Inborn lack of Treg’s?
IPEX
Four methods of Treg action to dampen immune response:
- immunosuppressive cytokines
- IL-10
- TGF-B
- IL-35 - IL-2 consumption –> apoptosis of effector T-cells
- cytolysis (granzyme mediated)
- CD152 (CTLA4) mediated modulation of DC’s
Over production of thyroid hormones caused by antibody agonists of thyroid stimulating hormones:
Grave’s disease
4 B-cell tolerance mechanisms:
- clonal deletion
- receptor editing (VDJ recombination) to avoid self reactivity
- Anergy –> downregulation of BCR, upregulation of CD5
- lack of T-cell help or survival factors
Th17 –> IL-17A –> ?
neutrophil recruitment
Th1 –> IFN-y –> ?
macrophage activation
Th2 –> IL-4, IL-5 –> ?
mast cell
B-cell –> antibodies
eosinophils
Defects in C1q, r, s predispose for:
SLE
Deficiency in C3 leads to:
increased susceptibility to bacterial infx
-immune complex disease
Homozygosity for CCR5 mutation:
resistance to primary spread of HIV-1
What is the role of CCR7?
expressed at high levels in Immunogenic DC’s
IL-13?
Th2’s
promotes help from humoral immune response
Autoantibodies to IL-17 and IL-22?
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