Regulation of the Immune Response Flashcards

1
Q

Key molecules involved in tolerogenic DC:T-cell interactions:

A

CD152 (CTLA-4)

IL-10

TGF-B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is meant by “tolerogenic”:

A

DC induction of clonal deletion or anergy of antigenic specific T-cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Inborn lack of Treg’s?

A

IPEX

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Four methods of Treg action to dampen immune response:

A
  1. immunosuppressive cytokines
    - IL-10
    - TGF-B
    - IL-35
  2. IL-2 consumption –> apoptosis of effector T-cells
  3. cytolysis (granzyme mediated)
  4. CD152 (CTLA4) mediated modulation of DC’s
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Over production of thyroid hormones caused by antibody agonists of thyroid stimulating hormones:

A

Grave’s disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

4 B-cell tolerance mechanisms:

A
  1. clonal deletion
  2. receptor editing (VDJ recombination) to avoid self reactivity
  3. Anergy –> downregulation of BCR, upregulation of CD5
  4. lack of T-cell help or survival factors
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Th17 –> IL-17A –> ?

A

neutrophil recruitment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Th1 –> IFN-y –> ?

A

macrophage activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Th2 –> IL-4, IL-5 –> ?

A

mast cell

B-cell –> antibodies

eosinophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Defects in C1q, r, s predispose for:

A

SLE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Deficiency in C3 leads to:

A

increased susceptibility to bacterial infx

-immune complex disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Homozygosity for CCR5 mutation:

A

resistance to primary spread of HIV-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the role of CCR7?

A

expressed at high levels in Immunogenic DC’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

IL-13?

A

Th2’s

promotes help from humoral immune response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Autoantibodies to IL-17 and IL-22?

A

APECED

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Auto inducing cytokine of Treg’s:

A

IL-35