ROS and Antioxidants Test Q's

Question 1

Impaired wound healing

Bleeding ecchymosis

swollen gums

anemia

enlargement and keratosis of hair follicles

lethargy

depression

Answer 1

Vitamin C deficiency

aka

Scurvy

Question 2

Found primarily in peroxisomes

highest in kidney and liver

reduces H2O2 to water to prevent it from forming hydroxyl radical via Fenton or Haber-Weiss rxns

Answer 2

Catalase

Question 3

Converts superoxide into hydrogen peroxide and O2

primary defense against oxidative stress

implicated in ALS !!!!

Answer 3

superoxide dismutase

Question 4

Caused by ROS derived from O2 in the blood that reenters previously hypoxic cells

Insufficiebt O2 = decreased ATP

Decreased ATP = increased Na+ and Ca2+

Answer 4

Ischemia-reperfusion injury

Question 5

life threatening recurrent infx from catalase POSITIVE organisms

genetic defect in NADPH oxidase

caseous necrosis

Answer 5

Chronic Granulomatous disease