Immunosuppressive drugs

Question 1

4 drugs that:

Interact with glucocorticoid receptors

–> GRE (glucocorticoid response elements)

–> NFkB –> suppress transcription

Answer 1

Prednisone

Methylprednisolone

Betamethasone

Dexamethasone

Question 2

Inhibits calcineurin via

NFAT pathway by binding

Cyclophilon

–blocks T cell activation

Answer 2

Cyclosporine

Question 3

Inhibits calcineurin via

binding to FK506

–blocks T cell activation

Answer 3

Tacrolimus

Question 4

Anti-proliferative

binds mTor

blocks progression of cell cycle from G1–S

Answer 4

Sirolimus

Question 5

Metabolite is an inhibitor of inosine monophosphate dehydrogenase (IMPDH)

inhibits B-cells and T-cells

Answer 5

Mycophenolate

Mofetil

Question 6

Ig binds to thymocytes in circulation –> lymphopenia and impaired T-cell response

Answer 6

Anti-thymocyte globulin (ATG)

Question 7

Antibody to CD3 on TCR

blocks T-cell activation

Answer 7

Muromanab-CD3

Question 8

Anti IL-2R’s (CD25) antibodies

blocks active T-cells and subsequent B-cell activation

Answer 8

Daclizumab

Basiliximab