Week 5 Angina Flashcards
1
Q
What is the effect of coronary arteriolar vasodilators in angina pectoralis and why?
A
Only dilate proximal to plaque as distal vessels are already maximum dilation
2
Q
What is common drug to treat angina?
A
GTN Glyceryl Trinitrate
3
Q
How does GTN cause vasodilation?
A
Aldehyde dehydrogenase in mitochondria of blood vessel wall converts GTN to NO
4
Q
Why is sublingual route used in angina?
A
To avoid first pass metabolism and ensure 100% bioavailability and quick effect
5
Q
What are the 3 mechanisms of oxygen balance in angina pectoralis?
A
Negative inotrope
Negative chronotrope
Antihypertensive
