Week 1 Kahoot Quiz ✅

Question 1

What is the route of GTN spray administration?

Answer 1

Buccal route

Question 2

Via which route would you administer medicine to a child with epilepsy?

Answer 2

Rectal route

Question 3

What is the definition of bioavailability?

Answer 3

Absorption and ability to get through liver and reach the systemic circulation

Question 4

What is a prodrug?

Answer 4

Activated by liver metabolism

Question 5

What property of a drug allows it to cross the BBB?

Answer 5

Lipid solubility

Question 6

What is the effect of a drug binding to plasma protein?

Answer 6

Enhances duration of action - healthy people do not excrete protein in urine

Question 7

How does Morphine cross the BBB?

Answer 7

It is a weak base

Question 8

What is Phase 1 metabolism?

Answer 8

Drug inactivation in liver

Question 9

What is Phase 2 metabolism?

Answer 9

Conjugation - production of water soluble metabolites

Question 10

Difference in excretion in urine of lipid and water soluble drugs?

Answer 10

Lipid soluble drugs passively reabsorbed in kidney, water soluble is excreted

Question 11

What may the effect be on a drug with reduced renal function?

Answer 11

Increased drug plasma concentration

Question 12

Why might codeine not be metabolised?

Answer 12

1 in 10 caucasians do not metabolise codeine due to genetic polymorphism

Question 13

What might the effect be of a drug with a liver inhibiting enzyme?

Answer 13

Increase plasma concentration

Question 14

What might the effect be of a drug with a liver inducing enzyme?

Answer 14

Decrease plasma concentration