Week 5

Question 1

Cytochrome c ?

Answer 1

Cytochrome c is primarily known for its function in the mitochondria as a key participant in the life-supporting function of ATP synthesis. However, when a cell receives an apoptotic stimulus, cytochrome c is released into the cytosol and triggers programmed cell death through apoptosis.

Question 2

Cytochrome c binds to an adaptor protein called Apaf1 (apoptotic protease activating factor-1), causing the Apaf1 to oligomerize into a wheel-like heptamer called an ___________.

Answer 2

apoptosome

Question 3

Atypical Cell Deaths:

Answer 3

Mitotic catastrophe
Anoikis
Excitotoxicity
Wallerian degeneration
Paraptosis
Pyroptosis
Pyronecrosis
Entosis

Question 4

__________ is a RNA-dependent DNA polymerase, reverse transcriptase, an enzyme that transcribes single-
stranded RNA into TTAGGG repeats and thereby elongates the telomeres.

Answer 4

Telomerase

Question 5

benign-malign tumor

Answer 5

remains confined to its site of origin-spreads throughout the body

Question 6

Hyperplasia-Dysplasia

Answer 6

benign-malign tumor

Question 7

Tumor suppressors are ________, Oncogenes are dominant.

Answer 7

recessive

Question 8

Diploidy?

Answer 8

existence of two chromosomes for each locus