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Musculoskeletal/Skin - WLB > Week 4 - Viral Skin Infections > Flashcards

Week 4 - Viral Skin Infections Flashcards

1
Q

What are the three methods viruses cause disease/damage?

A
  1. Lysis
  2. Immune-mediated damage
  3. Tumorgenesis
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2
Q

What are the three alphaherpesviruses?

A
  1. Herpes simplex 1
  2. Herpes simplex 2
  3. Varicella zoster virus
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3
Q

What are the three betaherpesviruses?

A
  1. HHV-6
  2. HHV-7
  3. Human cytomegalovirus (HCMV)
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4
Q

What are the two gammaherpesviruses?

A
  1. Epstein Barr virus (EBV)
  2. Kaposi sarcoma-associated herpesvirus (KSHV)
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5
Q

HSV-1 infects what? Reactivates where?

A

Infects: Mouth or pharynx

Reactivates above the waist.

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6
Q

HSV-2 infects what? Reactivates where?

A

Infects: genitals

Reactivates below the waist.

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7
Q

How is VZV spread?

A

airborne spread

or

close contact

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8
Q

What does VZV infect? Reactivates where?

A
  • Primary infection of the skin or respiratory tract, progresses through the blood to the immune cells of the endothelial system.
  • Reactivates from the dorsal root ganglia.
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9
Q

What is the single best screening procedure available for cervical cancer?

A

Pap smear

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10
Q

What finding in a pap smear is indicative of ongoing human papilloma virus?

A

Giant cells

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11
Q

How does human papilloma virus cause warts?

A

Causes actively replicating layers,

forces replicating cells to the surface.

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12
Q

What are the two viruses that cause wart-like eruptions?

A
  1. Human papilloma virus
  2. Molluscum contagiosum
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13
Q

What are the 5 main vesicular or pustular rash viral infections?

A
  1. HHV-1
  2. HHV-2
  3. VZV
  4. Coxsackieviruses A and B
  5. Smallpox
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14
Q

What are the 4 main maculopapular rash viral diseases?

A
  1. Measles
  2. Rubella
  3. Parvovirus B19
  4. Roseoloviruses (HHV-6 & HHV-7)
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15
Q

What does the herpesvirus gain entry into the nucleus through?

A

Nuclear Pore Complex (NPC)

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16
Q

What are the five layers of a herpesvirus?

A
  1. Surface glycoproteins
  2. Envelope
  3. Tegument
  4. Capsid
  5. Nucleus (DNA)
17
Q

How do herpesvirus infections last a lifetime?

A

Latency state:

Bind to host genome (chromosomes), but does NOT integrate into the host genome.

18
Q

What are the differences in lifecycles between alpha, beta, and gamma herpesviruses?

A

Alpha- go latent in neurons

Beta- go latent in B-cells

Gamma- go latent in T-cells

19
Q
A

Musculoskeletal/Skin - WLB (13 decks)

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