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Pharmacology Fall 2023 > Week 4 Reproductive & Genitourinary > Flashcards

Week 4 Reproductive & Genitourinary Flashcards

1
Q

Ethinyl Estradiol and Drospirenone (Yasmin) - Use

A
  • Prevention of pregnancy - reduces fluid retention from PMS - decreases risk for uterine and ovarian cancers, PID, benign breast disease and ovarian cysts
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2
Q

Ethinyl Estradiol and Drospirenone (Yasmin) - Adverse Effects

A
  • Thromboembolism - hyperkalemia - hypertension - uterine bleeding
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3
Q

Estrogen HRT: Conjugated Equine Estrogen (Premarin), Transdermal Estradiol (Estraderm, Climara, FemPatch), Intravaginal Estradiol (Vagifem) - Use

A
  • Relief of severe menopausal symptoms (vasomotor) and vulvar and vaginal atrophy - prevention of postmenopausal osteoporosis
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4
Q

Estrogen HRT: Conjugated Equine Estrogen (Premarin), Transdermal Estradiol (Estraderm, Climara, FemPatch), Intravaginal Estradiol (Vagifem) - Adverse Effects

A
  • Thromboembolism - pulmonary embolism / stroke / MI / hypertension
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5
Q

Estrogen plus Progesterone HRT: Conjugated Estrogen and Medroxyprogesterone Acetate (Prempro), Transdermal Estradiol and Norethindrone - Use

A
  • postmenopausal symptoms (vasomotor), and vulvar and vaginal atrophy - postmenopausal osteoporosis
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6
Q

Estrogen plus Progesterone HRT: Conjugated Estrogen and Medroxyprogesterone Acetate (Prempro), Transdermal Estradiol and Norethindrone - Adverse Effects

A
  • Thromboemblism - hypertension
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7
Q

GnRH Agonist: Leuprolide (Lupron) - Use

A
  • endometriosis - uterine fibroids - advanced prostate cancer
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8
Q

GnRH Agonist: Leuprolide (Lupron) - Adverse Effects

A
  • bone loss - vasomotor instability (hot flashes)
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9
Q

Progesterone: Medroxyprogesterone Acetate (Provera) - Use

A
  • endometriosis - dysfunctional uterine bleeding - endometrial carcinoma
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10
Q

Progesterone: Medroxyprogesterone Acetate (Provera) - Adverse Effects

A
  • thromboembolism - breast cancer
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11
Q

LH and FSH Stimulant: Clomiphene (Clomid) - Use

A
  • promotion of ovulation - treat infertility
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12
Q

Progesterone: Medroxyprogesterone Acetate (Provera) - Adverse Effects

A
  • vasomotor instability (hot flashes) - multiple gestation - breast engorgement
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13
Q

Ovulation Stimulant: Human Chorionic Gonadotropin (hCG) (Pregnyl) - Use

A
  • promotes ovulation - treats infertility
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14
Q

Ovulation Stimulant: Human Chorionic Gonadotropin (hCG) (Pregnyl) - Adverse Effects

A
  • ovarian hyperstimulation - ovarian cyst rupture - CNS effects (dizziness etc.)
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15
Q

Hyperprolactinemia Inhibitor: Cabergoline - Use

A
  • corrects amenorrhea from excessive secretion of prolactin - treats infertility
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16
Q

Hyperprolactinemia Inhibitor: Cabergoline - Adverse Effects

A
  • pulmonary fibrosis, pericardial fibrosis - CNS effects
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17
Q

Oxytocin (Pitocin) - Use

A
  • uterine stimulation - induction / enhancement of labor - postpartum hemorrhage
18
Q

Oxytocin (Pitocin) - Adverse Effects

A
  • uterine hyperstimulation - hypertensive crisis
19
Q

Ergot Alkaloids: Methylergonovine (Methergine) - Use

A
  • postpartum and post-abortion hemorrhage
20
Q

Ergot Alkaloids: Methylergonovine (Methergine) - Adverse Effects

A
  • hypertension - arrhythmias - seizures
21
Q

Synthetic Prostaglandins: Dinoprostone Vaginal Insert (Cervidil) or Gel (Prepidil) - Use

A
  • cervical ripening before labor - stimulation of uterine contractions
22
Q

Synthetic Prostaglandins: Dinoprostone Vaginal Insert (Cervidil) or Gel (Prepidil) - Adverse Effects

A
  • amniotic fluid embolism - CNS / GI effects
23
Q

Beta2 Adrenergic Agonists: Terbutaline (Brethine) - Use

A
  • preterm labor inhibition
24
Q

Beta2 Adrenergic Agonists: Terbutaline (Brethine) - Adverse Effects

A
  • respiratory effects - cardiac effects - hypokalemia - hyperglycemia - effects in fetus
25
Q

Glucocorticoids: Betamethasone (Betaject) - Use

A
  • increases production of lung surfactant to accelerate lung maturity in fetus between 24 - 34 weeks
26
Q

Glucocorticoids: Betamethasone (Betaject) - Adverse Effects

A
  • pulmonary edema - hyperglycemia - hypertension
27
Q

Anticonvulsant: Magnesium Sulfate - Use

A
  • prevent and treat seizure activity in pre-eclampsia or eclampsia
28
Q

Anticonvulsant: Magnesium Sulfate - Adverse Effects

A
  • depressed / absent DTRs - altered LOC - magnesium toxicity - decreased fetal heart rate
29
Q

Testosterone: Androderm, Delatestryl - Use

A
  • male hypogonadism - delayed puberty - testicular failure - treatment of breast cancer in females
30
Q

Testosterone: Androderm, Delatestryl - Adverse Effects

A
  • virilization - increased growth of existing prostate cancer - liver toxicity - gynecomastia - premature epiphyseal closure in young clients
31
Q

5-Alpha Reductase Inhibitor: Finasteride (Proscar) - Use

A
  • BPH (also reduces the risk of prostate cancer) - male pattern hair loss
32
Q

5-Alpha Reductase Inhibitor: Finasteride (Proscar) - Adverse Effects

A
  • reduced libido and ejaculate volume - reduced prostate-specific antigen (PSA) levels - gynecomastia
33
Q

Alpha-Adrenergic Receptor Antagonist: Tamsulosin (Flomax) - Use

A
  • BPH
34
Q

Alpha-Adrenergic Receptor Antagonist: Tamsulosin (Flomax) - Adverse Effects

A
  • reduced ejaculation volume. ejaculation failure - CNS effects
35
Q

PDE-5 Inhibitor: Sildenafil (Viagra) - Use

A
  • erectile dysfunction
36
Q

PDE-5 Inhibitor: Sildenafil (Viagra) - Adverse Effects

A
  • priapism - CNS effects
37
Q

Anticholinergics: Oxybutynin Chloride (Ditropan) - Use

A
  • urinary urge incontinence from overactive bladder - neurogenic bladder
38
Q

Anticholinergics: Oxybutynin Chloride (Ditropan) - Adverse Effects

A
  • dry mouth, urinary retention, constipation - CNS effects
39
Q

Cholinergics: Bethanechol (Urecholine) - Use

A
  • urinary retention
40
Q

Cholinergics: Bethanechol (Urecholine) - Adverse Effects

A
  • hypotension, bradycardia - bronchoconstriction - CNS effects

Pharmacology Fall 2023 (7 decks)

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