Week 4 - Cognition, Development & Psychopathology Flashcards
MZ correlation of g
.85
DZ correlation of g
.6
first-degree correlation of g
.45
C in g
.25
but disappears in adulthood
heritability g
around 60%
goes up with age
subscales of g and their heritability
heritability greater in verbal than in spatial
heritability and quality of environment for humans
the better the environment the higher the heritability
heritabiltiy and environment in rats
differences strongest in normal
what do teacher’s really assess
SES and ethnicity
assortative mating consequences
A goes down
C goes up
only for DZ
sibling earnings gap
frist borns have higher IQ
social explanation: more attention
there is also a biological one
missing heritabiliy
in GWAS
compared to twin data
the more complex a trait is the more is missing
endophenotype
easily measurable trait
seen as subscale of e.g. working memory -> IQ
head size
weight
first only C
then mostly A
upper bound of heritability
MZ correlation
historical theories on autism
refrigerator mom theory
slight brain damage
vaccinations
all wrong
relative risk
not the same as concordance
autism heritability
70-80%
ASD genetic correlations
negative with well-being
liability threshold
relatives of diagnosed person are often subclincal
risks for autism
multiple fevers in pregnancy
childhood toxin exposure e. g. lead
ADHD heritability
70%
ADHD correlates
positive with body size and smoking
negative with cognition
smoking heritability females
46%
indirect influence in smoking
the genes
direct influence in smoking
the cigarette
therapy with highly heritable disorders
family intervention is better
therapy for stable heritability
the earlier the better
assortative mating effect
higher C
lower A
but no higher rMZ
environment for rats
poor is damaging to bright and dull
enriched improved dulls
difference between dull and bright mostly in normal
school achievement heritability
highly heritable and stable
moderate cogntiive disability
between 35 and 50 IQ
three classic small chromosomal deletions
Prader-Willi syndrome
Williams syndrome
Angelman syndrome
families and cognitive impairment
mild is familial
severe not
most common cognitive disability
fragile X syndrome
Klinefelter syndrome
XXY
stability of heritability of ADHD
remains stable
heritability of anxiety disorder over life
decreases
autism and chromosomes
probably not X linked
Angelman syndrome
deletion in chromosome 15 from egg cell
Prader-Willi syndrome
deletion in chromosome 15 from sperm cell