Week 3 - From Genes to Behavior Flashcards
aims of genetics
identify gene variants
interpret biological differences
predict risks
shared between humans
99&
SNPs
single nucleotides that differ
found in only 0.1% of people
genotyping
sequencing of only the variable parts
GWAS disadvantages
confounds by environment
first GWAS
2005
GWAS plot
Manhattan plot
the higher the building the lower the very low p value of the association
gene for schizophrenia
C4 gene
too much pruning in puberty
common problem with GWAS results
risk increases tenfold, but is still low
other applications of genetics
noninvasive prenatal testing
criminology
alcoholism in old DSM
alcohol use disorder
alcohol dependence = physical symptoms
now they are the same
alcohol use three stages and their ACE
initiation: C, especially boys
frequency: A and E
problems: A
religious upbringing, gender and alcohol
no A only C for religious females
single liability model
initiation and dependency are the same
independent liability model
initiation and dependency are two dimensions
combined model
initiation and dependency are distinct, but correlated
heritability of cannabis between nations
the same, 44%
pharmocokinetic pathway
metabolism
pharmocodynamic pathway
neurotransmission
uses for linkage studies
single gene disorders
double gene disorders
complex disorders
affected sib-pair linkage design
how many alleles from specific DNA marker are in a family
weakness of allelic association study
can only detect functional genes or those close to them
correlation problem drinking and adopted children
0%
models for smoking
single liability
independent liability
combined model
