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Gene Environment Interaction > Week 3 - From Genes to Behavior > Flashcards

Week 3 - From Genes to Behavior Flashcards

1
Q

aims of genetics

A

identify gene variants
interpret biological differences
predict risks

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2
Q

shared between humans

A

99&

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3
Q

SNPs

A

single nucleotides that differ

found in only 0.1% of people

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4
Q

genotyping

A

sequencing of only the variable parts

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5
Q

GWAS disadvantages

A

confounds by environment

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6
Q

first GWAS

A

2005

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7
Q

GWAS plot

A

Manhattan plot

the higher the building the lower the very low p value of the association

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8
Q

gene for schizophrenia

A

C4 gene

too much pruning in puberty

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9
Q

common problem with GWAS results

A

risk increases tenfold, but is still low

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10
Q

other applications of genetics

A

noninvasive prenatal testing

criminology

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11
Q

alcoholism in old DSM

A

alcohol use disorder
alcohol dependence = physical symptoms
now they are the same

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12
Q

alcohol use three stages and their ACE

A

initiation: C, especially boys
frequency: A and E
problems: A

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13
Q

religious upbringing, gender and alcohol

A

no A only C for religious females

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14
Q

single liability model

A

initiation and dependency are the same

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15
Q

independent liability model

A

initiation and dependency are two dimensions

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16
Q

combined model

A

initiation and dependency are distinct, but correlated

17
Q

heritability of cannabis between nations

A

the same, 44%

18
Q

pharmocokinetic pathway

A

metabolism

19
Q

pharmocodynamic pathway

A

neurotransmission

20
Q

uses for linkage studies

A

single gene disorders
double gene disorders
complex disorders

21
Q

affected sib-pair linkage design

A

how many alleles from specific DNA marker are in a family

22
Q

weakness of allelic association study

A

can only detect functional genes or those close to them

23
Q

correlation problem drinking and adopted children

A

0%

24
Q

models for smoking

A

single liability
independent liability
combined model

Gene Environment Interaction (6 decks)

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