Week 4 - Cardiovascular Flashcards
Kawasaki disease
Acute generalized systemic small and medium vessel vasculitis occurring throughout the body. Macrophages invade the vasculature
Symptoms of Kawasaki Disease
Persistent fever for at least 5 days plus four of the following:
- bilateral conjunctival redness
- changes of the lips and oral cavity
- cervical lymphadenopathy
- polymorphous exanthema (swelling of the hands or feet) or perineal area
Six components when suspected Kawasaki’s disease but no complete diagnosis
- albumin ≤3.0 g/dL;
- urine ≥10 WBC/HPF;
- platelet count ≥450,000 after 7 days of fever;
- anemia consistent with age values;
- total white blood cell count ≥15,000/mm3; and
- elevation of alanine aminotransferase.
Kawasaki’s disease - acute phase
- Conjunctival hyperemia
- erythematous rash of hands and feet
- unilateral lymph node swelling
Kawasaki’s disease -subacute phase
- Fever, rash and cervical lymphadenopathy abate
- Arthralgias
- Desquamation of the skin over the fingertips
- Thrombocytosis (elevated platelets)
- Cardiac disease
Kawasaki’s disease -convalescent phase
- Starts around day 25
- Elevated ESR
- Abnormalities of the coronary vessels
- Myocarditis
Diagnosis of Kawasaki’s Disease
Diagnosis of exclusion. May run CBC with differential, ESR, CRP
Management of Kawasaki’s disease
- IVIG therapy
- High dose ASA for anti inflammatory properties
- Second dose IVIG
- Anticoagulation if coronary aneurysm is present
a. Warfarin
b. clopidogrel
Atrial Septal defect s/s
asymptomatic; older children may have fatigue, exertional dypnea, be thin, history of frequent URI or pneumonia
Atrial septal defect PE
- Murmur not noticed until 2-3
- Mild left anterior chest bulge
- S1 normal or split
- S2 widely split
- Grade 1-4 rating, medium pitched, not harsh systolic crescent-decrescendo
Diagnostics for atrial septal defect
X-ray shows cardiac enlargement
Management of atrial septal defect
- small defects may close on own
- large defects require closure through cardiac catheterization
- Aspirin or clopidogrel
Ventricular septal defect
Opening in septum between ventricles; most common congenital defect; most close spontaneously
Ventricular septal defect PE
- Low pitch grade 2-6 holosystolic murmur
- Thrill on left sternal border
- Signs of progressing CHF
- S3 or s4 gallop
Ventricular septal defect S/S
asymptomatic with small to moderate openings
infants with large openings exhibit symptoms (dyspnea, respiratory infections, diaphoresis, fatigue)