Week 4 Flashcards
What is MS?
Disease of the Central Nervous System
It is an immune-mediated inflammatory disease
It disrupts the flow of information within the brain, and between the brain and body.
How does MS work?
The disease attacks myelinated axons in the central nervous system, destroying the myelin and the axon in variable degrees.
what are the causes of MS?
it likely involves a combination of genetic susceptibility
and a presumed non-genetic trigger (e.g. viral infection, low vitamin D levels)
Geographic variation in the incidence of MS supports the probability that environmental factors are involved in the aetiology
How can MS manifest?
- Relapsing remitting
- Primary progressive
- Secondary progressive (when relapsing and remitting disease becomes progressive)
- Progressive relapsing (a combination of relapsing remitting and progressive from the outset)
What are the s&s of MS?
- Sensory loss
- Spinal cord symptoms
- Cerebullar symptoms
- eye symptoms
- trigeminal neuralgia
- facial myokymia
- constitutional symptoms
- Pain
- subjective cognitive difficulties
- depression
- euphoria
- bipolar disorder or frank dementia
- heat intolerance
what are some spinal cord symptoms of MS?
- Muscle cramping secondary to spasticity (motor)
* Bladder, bowel, and sexual dysfunction (autonomic)
what are some cerebellar symptoms of MS?
Charcot’s Neuroligical Triad” of ataxic dysarthria (syllables), intention tremor (ataxia), and nystagmus (dancing eyes)
What are some eye symptoms of MS?
– 33% of patients
– Optic neuritis: Unilatpain & blur
– Diplopia (Vert II not =)
– Lateral gaze
What are some facial myokymi symptoms of MS?
– Irregular twitching of the facial muscles
– May also be a presenting symptom
How do you treat MS?
- Corticosteroids:Methylprednisolone is the usual treatment given in acute attacks to reduce their severity
- Beta-interferon:(Betaferon,Avonex,Rebif): This SCI drug can reduce the rate of relapses by a third. This is often the first-line treatment for relapsing/remitting disease.
- Glatiramer acetate: (Copaxone): This drug is another immunomodifier that also reduces the frequency and severity of attacks.
- Oral immunosuppressants: Recently developed and show promise in reducing the number of attacks.
- Muscle relaxants: (baclofen, dantrolene, benzodiazepines): Can reduce the discomfort and pain of spasticity
- Oxybutinin: a bladder muscle antispasmodic
- Physiotherapy and Occupational Therapy: Important role
what is charcots neurological triad?
- Ataxic dysarthia
- intention tremor
- nystagmus
what is motor neuron disease?
Motor neuron disorders (MNDs) are a group of neurologic diseases characterized by progressive degeneration of motor neurons.
What is the most common form of MND in adults?
Amyotrophic Lateral Sclerosis
aka
Lou Gehrig Disease.
• It is a fatal disorder and is characterized by progressive skeletal muscle weakness and wasting or atrophy (ie, amyotrophy), spasticity, and fasciculations as a result of degeneration of the Upper and lower Motor Neurons, culminating in respiratory paralysis.
What are the characteristics of MND?
MND is a progressive, terminal neurological disease
Sufferers progressively lose the ability to walk, talk, feed themselves, swallow, and ultimately breathe
What are the causes of MND?
Most cases of MND are sporadic:
•Occurring in scattered or isolated instances without clearly identifiable causes.
There are many theories about the causes of MND:
•Exposure to environmental toxins and chemicals, infection by viral agents, immune mediated damage, premature ageing of motor neurons, loss of growth factors required to maintain motor neuron survival and genetic susceptibility.