Week 4 Flashcards
What is a Neutrophilis?
Most common white blood cell
What are the cellular components of inflammation?
Mast cell Neutrophilis Monocytes and macrophages Eosinophils Platelets
Where are Mast Cells located?
In connective tissue near blood vessels
What is phagocytosis?
Process of cell eating
What are the chemical mediators of inflammation?
Histamine Chemotactic factors Prostaglandins Plasma protein systems Cytokines
What do eosinophils do with the inflammation process?
Defend against parasites
Regulate vascular mediators released by mast cells
What do platelets do in an inflammation response?
When activated - involved in the clotting cascade
Degranulation
What is Prostaglandins?
Chemicals associated with pain Acute/chronic inflammation Increased vascular permeability Neutrophil chemotaxis PAIN
What is cox-1
Good Cox Constitutive physiological - platelet aggregation - GI mucosal integrity - Renal function
What is cox-2?
Bad Cox Inducible inflammatory - vasodilation - potentiate oedema - pain - cell growth/division Renal function Bone growth
What are the effects of systemic inflammation?
Sickness behaviour
- fever
- high BP
- malaise - generally feeling unwell
- loss of appetite
- fatigue
- leukocytosis - rapid division of white blood cells
What is cytokines?
A small protein released by cells that have a specific effect on the interactions between cells. Cells signalling (behaviour)
What are the phases of wound healing? (3)
1-acute inflammation
2-reconstruction phase
3-maturation phase
Primary Vs. secondary intention.
Primary
- wound healing from minimal tissue loss
Secondary
- wounds requiring a great amount of tissue replacement - open wound
What is dysfunctional wound healing?
Insufficient repair, excessive repair or infection.
Nutrient imbalance or existing health conditions contributing a negative effect.
