Week 2

Question 1

What is pharmacodynamics?

Answer 1

What the drug does to the body - interacts

Question 2

What is an Agonists?

Answer 2

Activate and bind to receptors to produce a response = Efficacy

Question 3

What is an Antagonist?

Answer 3

Bond to receptors but NO response = No Efficacy

Block/prevent receptor response.

Question 4

What is a competitive Antagonist?

Answer 4

Transient blockade

Can reverse agonist effects

Question 5

What are the 3 cell barriers?

Answer 5

1-Extra cellular
2-Membrane
3-Intracellular

Question 6

What is ADMET?

Answer 6

A - absorption
D - distribution 
M - metabolism
E - elimination
T - toxicity

Question 7

What is Albumin?

Answer 7

The protein which drugs bind to and travel in the plasma.
Albumin helps with maintaining blood pressure.
Helps with keeping fluid in blood stream

Question 8

What is the drug half life?

Answer 8

3 hours half the drug concentration is eliminated out of the body.

Depending on the drug the half life could be different. Liver damage could be 6 hours for the half life of the drug.

Question 9

What is pharmacokinetics?

Answer 9

The drug movement in the body
Drugs reach their site of action
Drug concentrations in the body change with time

Question 10

Weak Vs. Strong Agonists

Answer 10

Codeine - weak agonist because it doesn’t bind to the receptors good.
Morphine - strong agonist because it binds to the receptor really well.