Week 4 (1) Flashcards
Is urine normally sterile?
Yes
What is the lower end of the urethra colonised by?
Coliforms and enterococci from the large bowel
Name some causal organisms of UTI
Coliforms: E.coli klebsiella enterobacter proteus
What coliform is associated with the formation of stones (calculi)?
Proteus
What does proteus smell like?
Foul
What does proteus produce?
Urease which breaks down urea to form ammonia, which increases urinary pH - precipitation of salts
Name two enterococcus spp. that cause UTI - they are present in hte GI tract
- Enterococcus faecalis
2. Enterococcus faecium
What organism affects women of child bearing age?
Staphylococcus saphrophyticus - coagulase negative staph
What type of organism is pseudomonas aeruginosa?
Gram negative bacillus
What is pseudomonas aeruginosa associated with?
Catheters and UT instrumentation
What antibioitic treats pseudomonas aeruginosa (orally)?
Ciprofloxacin
Give three symtpoms and signs of UTI?
- Dysuria
- Frequency
- Haematuria
What is a Boricon container?
Contains boric acid (preservative) to stop bacteria multiplying - for urine
How long is there to deliver a urine sample in an sterile universal container?
2 hours
What - found of dipstick - ma indicate the presence of leukocytes in the urine?
Leukocyte esterase
What do nitrites found on dipstick suggest?
Presence of bacteria in urine
When doing microscopy of urine what should be looked for?
Presence of polymorphs (pus cells), bacteria and red cells
What is the Kass’s criteria?
Descibes the likelihood of UTI from a mid stream urine specimen
What does > 10^5 organisms in urine suggest?
Significant/probable UTI
What causes resistance to antibioitics in UTI?
ESBL - extended spectrum beta-lactamase
What is ESBL resistant to?
ALL cephalosporins and almost all penicillins
Where does ESBL come from?
Imported chicken
What antibiotics might be useful in ESBL UTI?
- Nitrofurantoin
- Pivmecillinam
- Fosfomycin
- Temocillin,. meropenem and ertapenem (IV)
Name organisms resistant to meropenam?
Carbapenemase-producing enterobacteriaceae (CPE) - gram negative coliform bacilli
What mediates resistance in CPE and what are they resistant to?
ALL current antibiotics and resistance is plasmid-mediated
Name four first line antibiotics for treating a UTI?
- Amoxicillin
- Trimethoprim
- Nitrofurantoin
- Gentamicin
What antibiotic inhibits bacterial folic acid synthesis?
Trimethoprim (oral)
When should trimethoprim be avoided?
In first trimester (3months) of pregnancy
What is there a risk of with co-trimoxazole?
SJS syndrome from sulphonamide
When should nitrofurantoin be avoided?
In late pregnancy (can cause neonatal haemolysis), breast feeding and children
When should gentamicin be avoided?
In pregancy. Risk of toxicity causing renal and 8th nerve damage
Does gentamicin treat pseudomonas?
Yes - should be prescribed for 3 days only
What antibiotic is 2nd line for UTIs, very betalactamase stable and is esterified form of mecillinam?
Pivmecillinam
What can cefalexin (broad spectrum) cause?
C.diff
What does ciprofloxacin (C.diff) inhibit?
DNA gyrase which prevents supercoiling of bacterial DNA
Name the only oral pseudomonas antibiotic?
Ciprofloxacin
What is the empirical treatment for Female lower UTI?
Trimethoprim or nitrofurantoin orally (3days)
What is the empitical treatment for uncatheterised male UTI?
Trimethoprim or nitrofuratoin orally (7days)
What is the empirical treatment for complicated UTI or pyelonephritis?
Co-amoxiclav or co-trimoxazole
What is the empirical treatment for complicated UTI or pyelonephritis (hospital)?
Amoxicillin and gentamicin IV (3 days)
Do you treat aysmptomatic bacteriuria?
Not if you dont have to, but treat in pregnancy
If asymptomatic bacteriuria in pregnancy is not treated - what two complications result?1
- 20-30% lead to pyelonephritis
2. Intra uterine growth retardation/premature labour
What are three causes of abacterial cystitis/urethral syndrome?
- Early phase of UTI
- Honeymoon cystitis
- / Chlamydia or gonorrhoea
How might abacerial cystitis symtoms be relieved?
Alkalising the urine
When should you give antibiotics to a catheter related UTI case?
ONLY if with fever or symptoms
Whast renal tumours are found in renal pelvis?
TCC
What renal tumours are found in renal parenchyma?
RCC
Name an embryonic renal tumour?
Nephroblastoms (Wilm’s tumour)
What causes a central scar on CT?
Oncocytoma
What is RCC classic triad?
- Loin pain
- Renal mass
- Haematuria
What staging is used for RCC?
Robson - mets: lungs, liver, bone and brain
Name two pre-malignanty penile cancer cutaneous lesions?
- Balanitis xerotica obliterans
2. Leukoplakia
What is balanitis xerotica obliterans?
White patches, fissuring, bleeding and scarring
What is erythroplasia of Queyraty?
SCC in situ on glans, prepuce or shaft
What are red velvety pathes on peis related to?
Zoon’s balanitis
What can be used to treat SCC in situ on penis?
Topical 5 fluorouracil
Give three clinical features of carcinoma of penis?
- Red raised area penis
- Fungating mass, foul smelling
- Phimosis
What investigation is advisable for primary tumour carcinoma of penis?
Ultrasound
When is peak incidence of carcinoma of penso?
80 years
In relation to carcinoma of penis - what lymph nodes might need to be sentinel biopsied or removed?
Inguinal
How are testicular tumpurs diagnosed?
Ultrasound and markers - AFT, HCG and LDH
What does HCG mark?
5-10% pure seminoma
60% teratoma
What does AFP mark?
Never raised in pure seminoma
What increases the risk of testicular tumours?
X30 with undescended testis
What do 100% of trophoblastic teratomas have raised?
HCG
What does heavy proteinuria present with?
Frothy urine
Is uraemia with pericarditis serious?
Yes
What should be examined in the presentation of renal disease?
BP and urinalysis
What should you mention in a renal systemic enquirey?
- Dyspepsia
- Dyspnoea
- Joint pains and arthralgia
- Skin rashes
What drug is hyperkalcaemia ia side effect of?
ACE inhibitors and arbs
What type of examinatin can cause acute kidney injury?
Radiology contrast
What is leukonychia?
White bands on nails suggesting hypoalbuminuria
What do granular urinary casts suggeset?
Indicative of chronic disease
What GFR in stage 1 kidney damage?
> 90
What GFR in stage 2 kidney damage
60-89
What GFR in stage 3 kidney damage?
30-59
What GFR in stage 4 kidney damage?
15-29
What GFR in stage 5 kidney damage?
Kidney failure
What is the nephrotic syndrome triad?
- Proteinuria
- Hypoalbuminaemia
- Oedema
What is defined as acute kidney injury, oliguria, oedema, hypertension and active urinary sediment?
Nephritic syndrome