Week 3 Flashcards
All adaptations of the human movement system are defined according to the ___ principle
All adaptations of the human movement system are defined according to the SAID principle
What does the SAID principle state?
Specific Adaptations can occur only in response to Imposed Demands
What is physical stress?
Adaptations imposed by mechanical loading
What are the ways to observe physical stress?
- Structural, functional, local and systemic changes
All adaptation begins at the ___ level
All adaptation begins at the cellular level
What is mechanotransduction?
The process by which the body converts physical stress into cellular responses
What do the the cellular responses from mechanotransduction promote?
Structural and functional adaptive change
What are the general steps of mechanotransduction?
- Mechano-coupling
- Cell to cell communication
- Effector response
What is mechano-coupling?
The mechanical trigger that initiates the process of mechanotransduction
What is the key to mechano-coupling?
The direct or indirect physical perturbation of the cell which is transformed into a variety of chemical signals both within and among cells
What is the critical point of understanding cell to cell communication?
The stimulus in one location, can lead to a distant cell registering a new signal, even though the distant cell did not receive a mechanical stimulus
What is the effector response?
The reaction to the mechanical stimulus to produce and assemble the necessary materials in the correct alignment for successful adaptation
What are the two pathways ignited by integrin proteins with movement in a tendon?
- Involves the cytoskeleton in direct physical communication with the nucleus( tension on the cytoskeleton sends a physical signal to the cell nucleus)
- Integrin acting on a series of biochemical signaling agents which after a series of intermediate steps, influence gene expression in the nucleus
What happens in the effector response once the cell nucleus receives the biochemical signals?
Normal cellular responses are engaged. mRNAs are transcribed and shuttled to the ER in the cell cytoplasm where is it translated into protein.
What happens to the protein in the effector response?
It is secreted and incorporated into extracellular matrix, hence the mechanical stimulus on the outside of the cell, promotes intra-cellular processes, leading to matrix remodeling
What are the characteristic responses of tissue to changes in the levels of physical stress?
- Maintenance of physical stress tolerance
- Increased physical stress tolerance
- Decreased physical stress tolerance
- Injury
- Death
When does the maintenance of physical stress tolerance occur?
When the physical loading is maintained in typical ranges and results in no apparent tissue change
When does the increase of physical stress tolerance occur?
When physical loading levels exceed maintenance range, but are still within adaptive capacity
What mechanism does increase muscle toleance to an increase of physical stress tolerance occur?
Hypertrophy
When does the decrease of physical stress tolerance occur?
When physical loading levels fall below maintenance range, resulting in decreased muscle tolerance in subsequent loading
What mechanism does increase muscle tolerance to an decrease of physical stress tolerance occur?
Atrophy
When does injury to tissues occur?
When physical loading levels exceed tissue tolerance beyond adaptive capacities
What are the things that can lead to injury of tissues?
- High magnitude loads of brief durations
- Low magnitude loads of long duration
- Moderate magnitude loads of excessive frequency or duration
Tissue injury results in ___ and initiation of the ___
Tissue injury results in tissue damage and initiation of the healing response
Tissue strain results in a structure with ____ and inflammation occurs, rendering tissue ____
Tissue strain results in a structure with lower load tolerance and inflammation occurs, rendering tissue even less tolerant to loading
Tissue death involves ___ exceeding the adult ultimate adaptive capacity of tissue in which there is a complete loss of tissue ___, ___, and ____
Tissue death involves extreme physical loading levels exceeding the adult ultimate adaptive capacity of tissue in which there is a complete loss of tissue vitality, function and recovery ability
What are the factors influencing the level of physical stress?
- Frequency
- Rate
- Duration
- Magnitude
- Type
What are the general effects fo prolonged stress deprivation/ immobilization?
- Loss of glycosaminoglycans (GAGs)
- Increased quantity collagen cross-links
- Randomized orientation of newly deposited collagen fibers
- Fatty fibrous infiltrations of edematous areas
- Pannus formation inside joints
- Generalized tissue atrophy
How do muscles adapt to immobilization in a shortened position?
- Decrease in number of sarcomeres with a compensatory increase in sarcomere length
- Increase in the amount of perimysium
- Thickening of endomysium
- Collagen fibril orientation becomes more circumferential
- Increase in ratio of connective tissue to muscle fiber tissue
- Loss of weight and muscle atrophy
How else do muscles adapt to immobilization in a shortened position?
- Adjusts sarcomeres to a length at which muscles is capable of developing maximal tension in immobilized position
- Displaces the length-tension relationship of the muscle so that maximum tension generated corresponds to immobilized position
- Muscle is able to generate maximal tension in the shortened position
- Muscle will not be able function effectively at joint it crosses immediately after cessation of the immobilization
How do muscles adapt to immobilization in a lengthened position?
- Fewer structural and functional changes than if immobilized in shortened position
- Increase in the number of sarcomeres resulting in a decrease in sarcomere length at the lengthened position
- Increased endomyseal and perimyseal connective tissue
- Muscle hypertrophy that may be followed by atrophy
- Increase in maximum tension-generating capacity
- Displacement of the length- tension curve to the longer immobilized position
What happens to tissues following prolonged immobilization and stress deprivation?
There is a decrease in adaptive abilities, with lower threshold for subsequent adaptation and injury due to prolonged low physical stress
What are the general effects of repeated stress exposure/ exercise?
- Tissues appear to respond favorably to gradual progressive loading by adapting to meet mechanical demands
- Responses vary among tissues and depends on nature of the stimulus
____ alters tissue structure and physiological function and has a direct effect on matrix alignment
Exercise alters tissue structure and physiological function and has a direct effect on matrix alignment
What does exercise lead to in tissues?
- Increased quantity of glycosaminoglycans
- Reduction of collagen cross links
- Functional orientation of collaged fibers in the connective tissues align accordingly to tissue stress
- Generalized tissue hypertrophy
- Increased load bearing capacity
What do glycosaminoglycans do?
Provide lubrication and maintain critical inner fiber distance between tissues
Exercise/ increased adaptive ability leads to ____ thresholds for subsequent adaptation an injury due to repeated stress exposure
Exercise/ increased adaptive ability leads to elevated/increased thresholds for subsequent adaptation an injury due to repeated stress exposure
____ forms the foundation for therapeutic preventative and restoration of exercise interventions
Elevated/increased thresholds for subsequent adaptation an injury due to repeated stress exposure forms the foundation for therapeutic preventative and restoration of exercise interventions
What is the response of bone to low, normal, high, and excessive physical stress?
- Low: Decreased bone mineral density and strength
- Normal: No change
- High: Increased bone mineral density and strength
- Excessive: Fracture
What is the response of cartilage to low, normal, high, and excessive physical stress?
- Low: Decreased proteoglycan content, thickness, and stiffness
- Normal: No change
- High: Increased proteoglycan content, thickness, and stiffness
- Excessive: Tear or degeneration
What is the response of ligament to low, normal, high, and excessive physical stress?
- Low: decreased cross sectional are, stiffness, and strength
- Normal: No change
- High: increased cross sectional are, stiffness, and strength
- Excessive: Sprain
What is the response of tendon to low, normal, high, and excessive physical stress?
- Low: decreased cross sectional are, stiffness, and strength
- Normal: No change
- High: increased cross sectional are, stiffness, and strength
- Excessive: Strain
What is the response of muscle to low, normal, high, and excessive physical stress?
- Low: decreased contractile protein, fiber diameter, peak tension, and peak power
- Normal: No change
- High: Increased contractile protein, fiber diameter, peak tension, and peak power
- Excessive: Strain
What is the response of neurons to low, normal, high, and excessive physical stress?
- Low: Decreased maximum discharge rate, increased recruitment threshold, decreased activation with maximum voluntary contraction, loss of neurons
- Normal: No change
- High: Inc maximum discharge rate, dec recruitment threshold, inc activation with maximum voluntary contraction, inc motor unit synchronization, inc dendritic arborization, inc serotonergic neural activity, inc synaptic transmission, and neurogenesis
- Excessive: Axonal demyelination and degeneration
What is the response of the heart to low, normal, high, and excessive physical stress?
- Low: dec cardiac muscle mass, capillary density, and stroke volume
- Normal: no change
- High: Inc cardiac muscle mass, capillary density, metabolic capacity, and stroke volume
- Excessive: Fibrosis, aneurysm, ventricular hypertrophy
What is the response of the blood vessels to low, normal, high, and excessive physical stress?
- Low: Dec vascular diameter and arterial compliance
- Normal: no change
- High: Inc vascular diameter and arterial compliance
- Excessive: Fibrosis, and aneurysm
What is the response of the skin to low, normal, high, and excessive physical stress?
- Low: Dec collagen content, collagen fiber diameter, strength, and thickness
- Normal: No change
- High: Inc collagen content, collagen fiber diameter, strength, and thickness
- Excessive: Abrasion or wound
What are the movement factors influencing tissue tolerance for physical stress?
- Muscle performance (force generation, muscle length)
- Motor control
- Postural alignment
- Physical activity
- Occupational, leisure and self care activities
What are the physiological factors influencing tissue tolerance for physical stress?
- Medication
- Systemic pathology
- Obesity
- Age
What are the psychological factors influencing tissue tolerance for physical stress?
- Depression
- Anxiety
- PTSD
What are the extrinsic factors influencing tissue tolerance for physical stress?
- Orthotic devices, taping, and AD
- Footwear
- Ergonomic environment
What are the age related changes in bone?
- Progressive loss of bone density
- Reduction in collagen cross linking
- Decrease in overall amount of bone tissue
- Slight decrease in size
- Decrease in strength and stiffness
- Increased brittleness
- Reduction of bone toughness
- Increased fragility
What are the age related changes in cartilage?
- Water content decreases
- Decrease in size of hydrodynamic aggrecan
- Changes in proteoglycan population that could be considered part of accumulated tissue damage
- Can contribute to vicious cycle of degenration
What are the age related changes in ligament and tendon?
- Number and quality of cross links increase beyond ideal level resulting in reduced tensile strength and stiffness
- Overall decrease in collagen fibril diameter
- Increased collagen fibril concentration through reduced water content
- Changes in active differentiated fibrocytes
- Reduced ability of growth factors to induce fibroblastic activity necessary to maintain tissue health and recover from injury
What do the changes in active differentiated fibrocytes include?
Including reduction in quantities, and alteration in their structure, reduction in inter-cellular communication and a reduced capacity for the mechanotransduction needed for collagen production and maturation
With age, fiber ___ and ____ changes
With age, fiber number and type changes
____ which is a loss of muscle mass results with aging
Sarcopenia which is a loss of muscle mass results with aging
Sarcopenia occurs through ___
Sarcopenia occurs through * a decrease in the size of the existing muscle fibers and the loss of muscle fibers
There is a ____ of proportion of fiber types with inactivity with age
There is a alteration of proportion of fiber types with inactivity with age
There is a gradual decrease in the number of type ___ fibers and a relative increase with type __ fibers with age
There is a gradual decrease in the number of type 2 fibers and a relative increase with type 1 fibers with age
The quantity of ___ decreases and the remaining ones have a higher number of fibers
The quantity of motor units decreases and the remaining ones have a higher number of fibers
The amount of connective tissue within extracellular matrix ___ with aging
The amount of connective tissue within extracellular matrix increases with aging
The increase in the amount of connective tissue within extracellular matrix with aging, may contribute to ___
- Contribute to decreased ROM
- Contribute to increased muscle stiffness
How does aging change muscle function?
- Decreased muscle strength
- Decreased muscle power which may ultimately contribute to falls
Tissue injury results in ___
Tissue injury results in tissue damage and initiation of healing process
What are the types of soft tissue injury?
- Strain
- Sprain
- Subluxation
- Dislocation
- Synovitis
- Hemarthrosis
- Ganglion
- Bursitis
- Contusion
What is a strain?
An over stretching, over exertion, or over use of soft tissue
The term strain is mostly used to refer specifically to ___
The term strain is mostly used to refer specifically to some degree of disruption to the muscular tendinous unit
What is a sprain?
A more severe stress, stretch or tear of soft tissues
The term sprain is most frequently used specifically to refer to ____
The term sprain is most frequently used specifically to refer to an injury of a ligament
What is a subluxation?
An incomplete or partial dislocation of the bony points of a joint that often involves secondary trauma to their surrounding soft tissue
What is a dislocation?
Usually in the bony points of a joint results in a loss of the normal anatomic relationships and leads to soft tissue damage, inflammation, pain, and muscle spasm
What is a synovitis?
A condition that involves inflammation of a synovial membrane, leading to an excess of normal synovial fluid in a joint or tendon sheath
What are the possible causes of synovitis?
Trauma or disease
What is hemarthrosis?
A condition that involves bleeding into a joint which is usually due to severe trauma
What is a ganglion?
A condition that involves the ballooning of the wall of the joint capsule or tendon sheath that may arise after trauma and sometimes occur with rheumatoid arthritis
What is a bursitis?
Inflammation of a bursa
What is a contusion?
A condition that involves bruising from a direct blow, resulting in capillary rupture, bleeding, edema, and an inflammatory process
What is an arthropathy?
A general term that refers to joint pathology
Arthritis involves ___
Arthritis involves inflammation of a joint
Arthrosis involves ___
Arthrosis involves degeneration of the cartilage of a joint often due to repetitive micro-trauma
What are the two types of arthropathy?
- Arthritis
- Arthrosis
What is a tendinopathy?
The general term that refers to tendon pathology
What are the types of tendinopathy?
- Tenosynovitis
- Tendinitis
- Tenovaginitis
- Tendinosis
What is tenosynovitis?
Inflammation of the synovial membrane covering a tendon
What is tenovaginitis?
Inflammation with thickening of a tendon sheath
What is tendinitis?
A condition involving inflammation of a tendon
What is tendinosis?
Degeneration of the tendon due to repetitive micro-trauma
When does a rupture/tear cause pain?
When the muscle undergoes a partial rupture or tear
Grade 1 (first degree) injury of a soft tissue injury occurs with…?
Disruption of small percentage of total number of fibers
What are the presentations of a grade 1 (first degree) soft tissue injury?
- Mild pain 0-24 hours after injury
- Mild swelling may occur
- Local tenderness and local pain with stress
What are the presentations of a grade 2 (second degree) soft tissue injury?
- Partial tear of structure
- Moderate pain leading to halt of activity
- Stress and palpation elicits increased pain
- When ligaments involved, results in some increased joint mobility
What are the presentations of a grade 3 (third degree) soft tissue injury?
- Near-complete to complete tear or avulsion
- Severe pain
- Stress to tissue is painless
- Anatomic defects palpable
- When ligaments involved, results in joint instability
What is hemostasis?
Arrest of bleeding primarily through physiological processes of vasoconstriction and coagulation so that blood is transformed from fluid to solid state
What are the two processes of soft tissue healing?
- Regeneration
- Repair
What is regeneration?
Process by which lost tissue is replaced by tissue of same morphological and functional characteristics
What is repair?
Process by which lost tissue is replaced by granulation tissue that forms into a mature scar
What are the cardinal signs of inflammation?
- Redness
- Warmth
- Swelling
- Pain at rest
- Loss of function
Where does regeneration of soft tissue occur?
In the cells of the epidermis, gastro-intestinal, gastro-urinary, respiratory tracts, and bone marrow
In ideal conditions, regeneration can occur in cells of the ___, ___, ___ and pancreas as well as with fibroblast, osteocytes, and endothelial cells and chndrocytes
In ideal conditions, regeneration can occur in cells of the endocrine glands, the liver, kidney and pancreas as well as with fibroblast, osteocytes, and endothelial cells and chndrocytes
Where does regeneration not occur?
Neurons, cells of the lens of the eye, cardiac muscle cells, and differentiated skeletal muscle cells
____ is the predominant healing process through which soft tissue in the MSK system undergo recovery
Repair is the predominant healing process through which soft tissue in the MSK system undergo recovery
What are the 3 phases of the repair process?
- Inflammatory
- Proliferative
- Maturation
What phase of healing is hemostasis?
The inflammation phase
___is crucial in precipitating the inflammatory response
Hemostasis is crucial in precipitating the inflammatory response
Damage to blood vessels and connective tissue cause ___ and ___ which releases endothelial cells, prostoglandins, and coagulation factor: thrombin
Damage to blood vessels and connective tissue cause bleeding and exposure collagen endothelium which releases endothelial cells, prostoglandins, and coagulation factor: thrombin
What does thrombin and the exposed collagen endothelium do?
They stimulate platelet activation
What do platelets do?
They bind to expose collagen and release fibronectin, which further stimulates platelet aggregation
Platelets release ___
Platelets release growth factors that facilitate cell proliferation, attraction of white blood cells and stem cells, cell differentiation and angioneogenesis
____ growth factor recruits fibroblast to the injured tissue and activates the production of collagen and glycoseminoglycans that are crucial for the repair of extra-cellular matrix
Platelet derived growth factor recruits fibroblast to the injured tissue and activates the production of collagen and glycoseminoglycans that are crucial for the repair of extra-cellular matrix
Platelets release non growth factor, ____ that increase capillary permeability, attract and activate microphages, induce tissue modulation and regeneration, and facilitate vasoconstriction
Platelets release non growth factor, cytokines that increase capillary permeability, attract and activate microphages, induce tissue modulation and regeneration, and facilitate vasoconstriction
Thrombin also converts coagulation factor ____ into fibrin with forms an inter-lacing lattice at the site of bleeding to promote clot formation
Thrombin also converts coagulation factor fibronigen into fibrin with forms an inter-lacing lattice at the site of bleeding to promote clot formation
Hemostasis is usually achieved under what time?
6-8 hours
Tissues that are highly vascularized or has sustained extensive damage may continue to bleed for how long following the onset injury?
1-2 days
Cytokines and growth factors released during the achievement of hemostasis facilitate the initiation of the ___
Cytokines and growth factors released during the achievement of hemostasis facilitate the initiation of the inflammatory response
___ stimulate vasodilation and increase permeability of capillaries, promote leakage of intra-vascular fluid, and cell migration into the area of injury and facilitate the local delivery of chemical mediators of the inflammatory process
Cytokines stimulate vasodilation and increase permeability of capillaries, promote leakage of intra-vascular fluid, and cell migration into the area of injury and facilitate the local delivery of chemical mediators of the inflammatory process
What do leukocytes do in the healing process?
They infiltrate the area and activate with the response, peaking within 2-3 hrs following the injury and lasting up to 2weeks.
Leukocyctes include ____ and ____
Leukocyctes include neutrophils and microphages
Why are leukocytes recruited to the area of injury?
In order to degrade and remove neucrotic tissue and microbes that might have invaded it
The process of degradation of that is done by leukocytes is called _____
The process of degradation of that is done by leukocytes is called phagocytosis
___ plays a significant role in the repair of damaged tissue, by releasing anti-inflammatory properties
Macrophages plays a significant role in the repair of damaged tissue, by releasing anti-inflammatory properties
How long does the inflammation phase usually last?
4-6 days
The inflammation response peaks in ___ hrs and lasts up to __ weeks following the initial injury
The inflammation response peaks in 2-3hrs and lasts up to 2 weeks following the initial injury
What are the primary goals for intervention in the inflammatory/acute phase of healing?
- Control effects of inflammation
- Facilitate wound healing
- Maintain normal function in unaffected tissues and body regions
What are the patient education actions that should be taken during the inflammatory/acute phase of healing?
- Expectations for the inflammation phase of healing
- Activity recommendations
- Precautions and contraindications
- Reassurance that the phase is necessary
How should the site of injury be protected during the inflammatory/ acute phase of healing?
- Relative rest
- Possible supportive or adaptive devices
- Reduction of swelling
What are the movement interventions that should be done during the inflammatory/ acute phase of healing?
- Controlled passive movement
- Tissue-specific activities
- General active movement of neighboring regions
What are the primary goals for intervention in the proliferation/subacute phase of healing?
• Initiation of active movement
• Progression of activities within
tolerance of healing tissues
• Management of pain and inflammation
Controlled passive movements may be used to promote ___ while preventing
Controlled passive movements may be used to promote *the development of organized scar while preventing disruption of tissue fibrils forming at the site of healing
Tissue specific activities may be appropriate with ___
Tissue specific activities may be appropriate with general joint motion when articular structures are involved and general muscle setting when musculo-tendinous structures are involved
General active movement of neighboring regions is appropriate to maintain the ___ as well to aid in circulation an lymphatic flow
General active movement of neighboring regions is appropriate to maintain the integrity of uninjured tissues as well to aid in circulation an lymphatic flow
The proliferation phase overlaps into the inflammation phase due to the dual role of the ____ as they act first in phagocytosis and then in the release of anti-inflammatory mediators
The proliferation phase overlaps into the inflammation phase due to the dual role of the macrophages as they act first in phagocytosis and then in the release of anti-inflammatory mediators
At the proliferation phase noxious stimuli are ___ and ____ begin to grow into the are
At the proliferation phase noxious stimuli are removed and capillary beds begin to grow into the are
____ is a hallmark of the proliferation phase
Fibroblast is a hallmark of the proliferation phase
Fibroblast are initially brought to the area of injury by ___
Fibroblast are initially brought to the area of injury by platelets
_____ and ____ release growth factors to perpetuate the migration of further fibroblast into the injured area
Macrophages and fibroblast themselves release growth factors to perpetuate the migration of further fibroblast into the injured area
Through the proliferation of fibroblast, large amounts of ____ are produced with a laying down of the collagen fibers and the development of ____ tissue
Through the proliferation of fibroblast, large amounts of extra-cellular matrix are produced with a laying down of the collagen fibers and the development of granulation tissue
During the proliferation phase, the immature connective tissue that is produced is ___ and _____. It is extremely fragile and easily _____ if stressed excessively
During the proliferation phase, the immature connective tissue that is produced is thin and unorganized. It is extremely fragile and easily injured if stressed excessively
How can proper growth and alignment of connective tissue be stimulated in the proliferation phase?
It can be stimulated by appropriate tensile loading in the line of normal stress for the tissue
_____ is characteristic of the proliferation phase
Contraction is characteristic of the proliferation phase
Contraction of the wound involves inward movement of wound edges by the action of ____
Contraction of the wound involves inward movement of wound edges by the action of myo-fibroblast
_____ appear at the wound site at about 5 days after the injury and becomes prominent over the next few days.
Myo-fibroblast appear at the wound site at about 5 days after the injury and becomes prominent over the next few days.