week 2 mystery of amyloid Flashcards
what is amyloid
misfolded proteins deposited between cells that cannot be broken down by the body
what is an inflammatory protein that is the source of amyloid
SAA
type of amyloid is classified based on
the source of the amyloid fibril
amyloidosis is:
the result of the abnormal folding of proteins
misfolded proteins are deposited as
fibrils in tissue
once proteins are deposited, what do they do
they disrupt normal function of tissue
normal proteins misfold and then are _____
degraded by cells
AA amyloid is the result of
misfolding of SAA
where is saa normally found
liver in acute inflammation
deposition of the amyloid protein often must be associated with
either a defect in the normal degradation process or abnormalities in the SAA protein which results in resistance to normal enzymatic degradation
grossly: amyloid deposits
tissue is enlarged, pale, and somewhat firm
lugol’s idoine is used and stains amyloid
black
H&E stain : amyloid appears
homogenous, eosinophilic, extracellular deposit that expands the intracellular spaces
congo red stain: amyloid appears
red-orange and exhibits apple-green birefringence when viewed with polarized light
