Week 2 antihistamine Flashcards
histamine
locally acting compound plays a role in allergic reaction
cause symptoms of mild allergy like rhinitis, itching, localized edema
physiologic and pharmacologic effect of Histamine
vasodilation
increased capillary permeability
bronchoconstriction
promotes secretion of mucus , gastric acid
also havea role in cognition, sleeping walking cycle, seizure suppression*
two type of anti-histamine antagonists
H1 receptor antagonist ( treat the mild allergic disorder, motion sickness, OTC sleeping aid )
H2 receptor antagonist ( treat gastric and duodenal ulcers)
First gen H 1 receptor antagonist
smaller molecules, crosses blood Brian barriers, high affinity to H 1 receptor in the Brain, HENCE, causes more daytime sedation
antichilingeric effect
diphenhydramine (dolphin hydra )
phenothiazine (pro moth sailing )
chlorpheniramine (color fin mime
second gen H 1 receptor antagonist
Fexofenadine ( Allegra ). fox-fenced —do not take it with fruit juice
cetirizine ( zyrtec ) citrus magazine
loratadine ( Claritin)
low-rationing
cycloooxygenase inhibitor (COX inhibitor )
anti- inflammatory
Moa - inhibit enzyme cyclooxyrgenase that responsible for synthesis prostaglandin
cycloooxygenase inhibitor (COX inhibitor )
anti- inflammatory
Moa - inhibit enzyme cyclooxyrgenase that responsible for synthesis prostaglandin
cycloooxygenase
enzyme s
cycloooxygenase
enzyme catalyze PGE2 and PGI2 at site of tissue injury to promote inflammation and sensitized receptor for pain
in stomach it promotes synthesis of prostaglandin, reduce gastric acid secretion, increase secretion of bicarb which help protect gastric mucosa
stimulate platelet aggre
cycloooxygenase
enzyme catalyze PGE2 and PGI2 at site of tissue injury to promote inflammation and sensitized receptor for pain
in stomach it promotes synthesis of prostaglandin, reduce gastric acid secretion, increase secretion of bicarb which help protect gastric mucosa
stimulate platelet aggregation
in kidney COX promotes vasodilation thereby maintain renal blood flow
contract uterus
CNS - mediate fever, and perception of pain
inhibition of COX 1 (good COX)
protect against MI and stroke secondary to reduced platelet aggregation )
S/E gastic ulceration
bleeding tendencies
renal impairment
Inhibition of COX-2
inhibition of COX-1 (good COX)
protect against MI and stroke secondary to reduced platelet aggregation )
S/E gastic ulceration
bleeding tendencies
renal impairment
Inhibition of COX-2 ( bad COX)
suppress inflammation alleviate pain
reduce fever
protect against colorectal cancer
S/E renal impairment
promote storke secondary to suppress vasodilation
