anticoagulant Flashcards
vitamin K dependent clotting factor
VII, IX, X, II
Drugs that activate antithrombin
heparin
enoxaparin (lovenox)
vitamine antagonist
Warfarin
direct thrombin inhibitor
Dabigatran ( Pradaxa)
direct factor Xa inhibitor
Rivaroxban (Xarelto)
apixaban (elquis)
Antiplatelet
aspirin
Clopidogrel (plavix )
vorapaxar (Zontivity)
arterial thrombosis
begin with adhesion of the platelet stimulated by damage to the wall or rupture of the atherosclerotic plaque )
venous thrombosis
develop due to blood stagnation initiates the coagulation cascade, result in the production of fibrin
venous thrombosis
develop due to blood stagnation initiates the coagulation cascade, result in the production of fibrin
Heparin
surpassed the coagulation by enhance the ability of anti-thrombin ( by binding and conformation change )to inactivate thrombin and factor X and subsequently surpassed the formation of fibrin
preferred anti-coagulant to use in pregnancy
situation that requires rapid onset of anticoagulant – PE, DVT
and open heart Sx ,dialysis, MI
adverse effect of heparin
hemorrhage
heparin induced thrombocytopenia
heparin should be stopped if platelet is < 100,000 mm3
LMW heparin
Perferentially inactive factor Xa, less effective in inactive thrombin imcomhparsion to heparin due to shorter pentasccharide sequence
therapeutic use ofc LMW heparin
prevention of DVT after abdominal surgery, hip replacement
tx of established DVT
prevention of ischemic complication in pt with unstable angina, non Q wave MI, STEMI
when use for prophylaxis or tx for DVT, LMW heparin is more effective than unfractionated heparin
Warfarin
hash a delay onset, hence is inappropriate for emergency
long term prophylaxis
MOA Of warfarin
vita K antagonist
surpassed coagulation y decrease production of clotting factor VII, IX, X and II ( prothrombin )
