Week 2

Question 1

sjogrens antibodies

Answer 1

anti ro, anti la

Question 2

which connective tissue disease puts you at increased risk of lymphoma

Answer 2

sjogrens

Question 3

what are the two types of systemic sclerosis

Answer 3

diffuse and limited

Question 4

antibodies in systemic sclerosis

Answer 4

anti-centromere (more associated with limited), anti-Scl-70 (more associated with diffuse)

Question 5

raynauds is usually one of the earlier symptoms of limited systemic sclerosis, true or false

Answer 5

true

Question 6

systemic sclerosis facial changes

Answer 6

small puckered lips, “beaked”/”hooked” nose, thickened/tight skin, telangiectasia

Question 7

systemic sclerosis related GI complications

Answer 7

dysphagia, GORD, watermelon stomach, malabsorption, fluctuating bowel habit, faecal incontinence

Question 8

systemic sclerosis cardio/resp complications

Answer 8

ILD, Pulmonary Arterial Hypertension, Myocardial disease

Question 9

systemic sclerosis renal complications

Answer 9

scleroderma renal crisis - rapid deterioration of kidney function along with high uncontrolled BP

Question 10

an interchangeable name for systemic sclerosis

Answer 10

scleroderma

Question 11

what is systemic sclerosis

Answer 11

a multisystem autoimmune disease characterised by vasculopathy, autoimmunity and fibrosis

Question 12

classic symptoms of systemic sclerosis

Answer 12

raynauds, polyarthralgia, skin thickening, difficulty swallowing, GORD, telangiectasia, calcinosis, +/- SOB

Question 13

three phases of raynauds

Answer 13

blanching, acrocyanosis, reactive hyperaemia

Question 14

first line treatment of vasculopathy/raynauds in systemic sclerosis

Answer 14

CCB - nifedipine

Question 15

peak incidence of systemic sclerosis

Answer 15

age 30-50

Question 16

what is in the Reiter’s syndrome triad?

Answer 16

urethritis
conjunctivitis/uveitis/iritis
arthritis

Question 17

what is Reiter’s syndome

Answer 17

a form of reactive arthritis

Question 18

first line pharmacological treatment for spondyloarthropathies

Answer 18

NSAIDs

Question 19

features of spondyloarthropathies

Answer 19

HLA B27
affect spine/joints
enthesitis
extra articular features

Question 20

pneumonic to remember the spondyloarthropathies

Answer 20

PAIR
Psoriatic arthritis
Ankylosing spondylitis
IBS/enteropathic
Reactive arthritis

Question 21

what does synovitis mean?

Answer 21

inflammation of joint and tendon sheath linings

Question 22

what does enthesitis mean?

Answer 22

inflammation at sites where ligaments and tendons attach to bones e.g. Achilles tentinitis, plantar faciitis

Question 23

what does dactylitis mean?

Answer 23

inflammation of the entire digit (sausage finger or toe)

Question 24

what is schober’s test used for?

Answer 24

to measure lumbar spine flexion. a positive test may indicate ank spond

Question 25

lungs- upper lobe fibrosis can occur in ank spond, true or false

Answer 25

true

Question 26

what condition may show bamboo spine as a complication on xray

Answer 26

ankylosing spondylitis

Question 27

What are the ANCA-associated small vessel vasculitides

Answer 27

Granulomatosis with polyangiitis (GPA) aka Wegener's Microscopic Polyangiitis (MPA) Eosinophilic granulomatosis with polyangiitis (EGPA) aka Churg-Strauss syndrome

Question 28

is Henoch-schonlein purpura an ANCA-associated or a non-ANCA associated small vessel vasculitis

Answer 28

non-ANCA associated