Week 12 - Topic 3: Lower Respiratory Tract Infections Flashcards
Name 5 viruses that cause bronchiolitis or viral pneumonia…
- Respiratory syncytial virus
- Human metapneumovirus
- Parainfluenza virus
- Adenovirus
- Influenza A/B
- Epstein-Barr virus (mononucleosis)
What is the most common cause of bronchiolitis or viral pneumonia in children?
Respiratory syncytial virus RSV
How do you treat someone with RSV?
Supportive care
Nasal/oral suctioning, cardio+resp+T° monitoring, hydration
What is given to high risk infants/children to prevent RSV?
Monthly palivizumab (RSVIg) IM during season
What are symptoms of influenza?
Fever + cough AND 1 or more of:
sore throat, arthralgia (joint pain), myalgia (muscle pain), weakness
Who may experience GI symptoms during influenza?
Children <5 y.o.
What are the two influenza strains that circulate during flu season?
A and B
C is very uncommon and thus not found in vaccines
Which influenza strain causes the most outbreaks and why?
A
It is highly contagious and mutates a lot
What virus belongs to the orthomyxoviridae family?
influenza
What are 4 element of influenza morphology?
1) Surface proteins (M1 and M2)
2) Hemagglutinin antigen
3) Neruaminidase antigen
4) Viral RNA
How do we identify the influenza viruses?
Based on the 18 hemagglutinin antigen sub-types and the 11 neuraminidase antigen sub-types
What is an antigenic shift?
Major shift in a virus from mutations –> causes pandemics
What is an antigenic drift?
Small mutations in a virus –> why there is a new influenza vaccine every year
What is the ecological cycle of influenza A viruses?
Birds share it amongst each other -> give it to chickens -> give it to pigs (mixing vessel) –> give it to humans
Why are there no influenza B pandemics?
No shifts recorded (doesn’t mutate) and no known animal reservoirs
How are the viruses selected for the seasonal influenza vaccine?
Labs from 5 WHO centers around the world gather to determine which virus is circulating in February to have the vaccine available in November for flu season (Northern Hemisphere)
How long does it take to build up immunity from the influenza vaccine? With this in mind, what must you do ideally?
2 weeks
So you might still get the flu within 2 weeks after vaccine administration
Get immunized as early as possible during flu season!
How long are you protected with the flu vaccine?
5-6 months