Week 10 Protein Metabolism Flashcards
What is the function of protein?
Structural proteins
Transport
Enzyme function
Hormones
What is the structure of amino acids?
An amino group-two hydrogen atoms and a nitrogen atom
A carboxyl group (COOH)
In the middle there is an organic chain that consists of (C, O, H, N, S)
What are the proteins held together by?
Peptide bonds
What type of reaction form a peptide bond?
A condensation reaction
What causes the primary protein structure?
Amino acid sequence
What causes the secondary protein structure?
Hydrogen bonds between amino acids within the peptide chain
What causes the tertiary protein structure?
Attractions between alpha-helices and beta sheets
What causes quaternary protein structure?
Two or more peptide chains form a create the building blocks of a functional enzyme
What happens if the protein is denatured?
Loss of structure and biological activity
Is protein stored as an energy substrate?
No
What is the turn over rate of protein?
Fast turnover rate
What is protein a rapid response to?
Starvation
Training
How is protein metabolism regulated?
By hormones
What are the enzymes that regulate protein turnover?
Proteinases
Peptidases
Why is protein as an energy source minimal in exercise?
Nitrogen excretion requires ATP expenditure
Can all amino acids be degraded?
Yes
What does amino acid degradation require? What is it known as?
Removal of nitrogen from the amino acid molecule (deamination)
What can the protein enter TCA cycle as?
Pyruvate
Acetoacyl-coA
Acetyl-coA
When nitrogen is released from amino acids what is released?
Ammonia (NH3+)
What is used to transport ammonia?
Alanine and glutamine
What is occurring in the body if you have a negative nitrogen balance?
Muscle wastage
What do proteins consist of?
Amino acids
What is deamination?
A process where the amino group (NH2) is removed from a protein molecul
After deamination what happens to the amino group and the carbon skeleton?
Amino group is converted into urea (using ATP)
Carbon skeleton can then enter the TCA cycle