Week 10 cardiovascular system blood part 1 Flashcards
Overview
Cardiovascular system/ circulatory system is comprised of these components;
-Circulating gases, nutrients and wastes
-Blood, vessels and heart
These components ensure that the body gets all the nutrients it needs to function and that waste products are removed effectively
Blood
Blood is a vital fluid that sustains life by performing essential functions, it acts as a transport carrier, providing various critical functions including; transportation, protection and regulation
Blood function, transportation
-O2, CO2 and other gases movement
-Nutrients
-Electrolytes
-Metabolic waste
-Hormones, Cytokines
O2 and CO2 movement
Oxygen transport; Blood carries oxygen from the lungs to the tissues throughout the body via red blood cells bound to haemoglobin
Carbon dioxide transport; Blood transports carbon dioxide, a waste product of metabolism, from the tissues back to the lungs for exhalation
Nutrients
Blood distributes nutrients absorbed from the digestive system to all cells in the body, providing the necessary fuel and building blocks for cellular function
Electrolytes
Blood carries electrolytes such as sodium, potassium, calcium and bicarbonate, which are essential for maintaining cellular function, nerve transmission and muscle contraction
Metabolic waste
Blood transports metabolic waste products e.g., urea and creatinine to the kidneys for excretion -> helps maintain homeostasis
Hormones and cytokines
Blood delivers hormones and cytokines, which are signalling molecules that regulate various physiological processes, including growth, metabolism and immune responses
Antibodies and complement proteins
-Immune response Antibodies and complement proteins;
Blood contains antibodies (immunoglobulins) and complement proteins that help to identify and neutralise pathogens
-Blood loss-Clotting (platelets)
Blood function, regulation
-Body temp
-pH
-Circulatory body fluid volume / concentration (osmosis)
Blood characteristics
A liquid connective Tissue (only fluid tissue in the Human Body)
-A sticky viscous opaque fluid
->Scarlet Red: High Oxygen (in Artery)
->Dark Red: Low Oxygen (in vein)
-Blood volume: 1.2 to 1.5 Gallons: 8-10% of body weight
-Male: 5-6 L; Female: 4.5L
Blood plasma
Plasma: Straw-coloured sticky fluid
~90% water
~10% soluble components
- Plasma proteins- Albumin, globulin, fibrinogen
- Nutrients- Glucose, Amino acids, Cholesterol
- Gases- O2, CO2, traces (little bit <1%)
- Electrolytes- Sodium, Potassium, Chlorides & others
- Metabolic wastes- Urea
Haematopoiesis
Blood cell formation;
Red bone marrow in, Axial skeleton, Girdles, Epiphyses of humerus and femur
Haematopoietic stem cells/ Haemocytoblast:
-Formation of RBC, WBC and Platelets
-Hormonal/Growth factors determine the type of cells
-Produced cells enter through
blood sinusoids
Blood, white blood cells
In buffy coat
A key part of the immune system, WBCs protect the body against infections and foreign invaders
Neutrophils
The most abundant type, involved in the initial immune response
Lymphocytes
Include B-cells and T-cells, key players in adaptive immunity
Monocytes
Differentiate into macrophages and dendritic cells, involved in phagocytosis and antigen presentation
Eosinophils
Combat multicellular parasites and are involved in allergic reactions
Basophils
Release histamine and other mediators involved in inflammatory responses
Blood, platlets
Also known as thrombocytes;
-Cell fragments
-Contains mitochondria but no nucleus
Function: Play a crucial role in blood clotting and preventing blood loss from damaged vessels
(buffy coat)
High WBC count
Philia: Surplus/Excess
Cytosis: Increase
Low WBC count
Penia: Deficiency/not enough
Leukopenia (low white blood cell count), Risk of infection, Sepsis and Letha
Neutropenia (low neutrophils), Risk of bacterial infections
Thrombocytopenia (low platelets), the risk of blood loss, an autoimmune condition in children
Haemoglobins
-Haem – Red pigment bound to Protein, Globin
Haem contains central Iron
Each Fe2+ ion binds to one O2
Four polypeptides -> 2 Alpha & 2 Beta
One Hb transport 4 O2 molecules
High WBC count 2
Leucocytosis: Sign of Infection
Neutrophilia -> (Neutrophil Leucocytosis)
-Sign of Bacterial Infection, pneumonia
->Eosinophilia, sign of parasitic Infection, helminthiasis
->Lymphocytosis, sign of viral Infection, hepatitis
->Monocytosis, sign of bacterial Infection in tissues, TB
Red blood cells
Erythrocytes
-Men – 4.7 to 6.1 million cells per microlitre (cells/mcL)
-Women – 4.2 to 5.4 million cells/mcL
-Biconcave- no nucleus and organelles (Large surface area for exchange)
(Anaerobic ATP synthesis, don’t use O2)
-97% of RBC is Haemoglobin – Gas Transport: Oxygen (Reversible binding)
-Spectrin, a plasma membrane protein- (Flexibility of shape- to get throughnsmaller capillaries)
Haemoglobin and gas transport -> O2
O2 (loading) + Hb= Bright Red (OxygenatedBlood):
Oxyhaemoglobin
98-100% saturated O2
O2 (unloading) + Hb= Dark/Ruby Red (Deoxygenated Blood):
Deoxyhaemoglobin
75-80% saturated O2
Haemoglobin and gas transport -> CO2
CO2 (loading) + Hb= ~20% of CO2 bound Hb:
Carbaminohaemoglobin