Week 1 Wound Healing Flashcards
what are the three phases of healing
inflammation
proliferation
maturation and remodeling
what two responses do you get in inflammation
vascular and cellular response
what is the goal of the vascular response
control bleeding, fight infectious agents
describe the vascular response
transudate leaks out of the vessel walls, and you get local edema. This cases local blood vessels to constrict. platelets aggregate and active and a plug is formed, which walls off area and closes lymph channels. MORE edema. so chemical mediators are released
within 30 minutes of vasoconstriction, what occurs
vasodilation
what 3 things result from vasodilation
localized redness, warmth and edema
what are the cardinal signs of inflammation
edema, redness, warmth, pain, decreased function
what is the cellular inflammatory response
you get an increase in leakiness vessel walls, and pushes polymorphonuclearneutrophils (PMNs) to the sides of the vessel walls. the macrophages arrive and kill pathogens and direct the repair process. Finally, mast cells produce histamine and secrete enzymes to accelerate the riddance of damaged cells
what are the key cells in the cellular inflammatory response
platelets, PMNs, macrophages, mast cells
what are the first to arrive at the site of the injury, what do they do? and what do they secrete
PMNs arrive within the first 24 hours, kill bacteria and clean, then secrete matrix metalloproteases (MMPs)
what is proliferation
this is where you get angiogenesis (formation of new blood vessels), granulation tissue and wound contracture. finally, you get epithelialization
what is angiogenesis
formation of new blood vessels
what si granulation tissue
fibroblasts lay down extracellular matrix, which will eventually be replaced by scar tissue
what is wound contracture
myofibroblasts pull wound margin together
what is epithelialization
keratinocytes and epidermal appendages multiply and migrate across the wound bed
what happens in the maturation phase
granulation tissue must be strengthened and reorganized, rapid collagen synthesis
how long does maturation last
up to 2 years following the wound closure
when do you see the greatest change in the maturation phase
in the first 6-12 months